Recombinant Human EPH Receptor A6, GST-tagged

• Cat.No.: EPHA6-1012H
• Product Overview: Recombinant human EPHA6 (561-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Cat. No.: EPHA6-1012H
• Description: EPHA6 is a member of the ephrin receptor subfamily of protein-tyrosine kinases which have been implicated in axon guidance, neuron-target interactions, regional compartmentalization, and synaptic functions in nervous systems. EPHA6 is highly expressed in the brain and testis. Reduction in EPHA6 has been detected in Hypospadias, a common defect affecting the growth and closure of the external genitalia. Genetic inhibition of EPHA6 in mice produces behavioral deficits specifically in tests of learning and memory. Mice deficient in EPHA6 show reduced memory of the consequences of the training context.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 73 kDa
• Expression System: Sf9 insect cells using baculovirus
• Species: Human
• Form: Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
• Specific Activity: 9.0 nmol/min/mg
• Purity: > 70 %
• Concentration: 0.1 ug/ul
• Sequences: 561-end
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Axon guidance; EPHA forward signaling; EphrinA-EPHA pathway

Gene Information

• Gene Name: EPHA6 EPH receptor A6 [ Homo sapiens ]
• Official Symbol: EPHA6
• Synonyms: EPHA6; EPH receptor A6; UNQ6114; DKFZp434C1418; EPA6; FLJ35246; PRO57066; ephrin type-A receptor 6; EHK-2; OTTHUMP00000214353; ephrin receptor EphA6; OTTHUMP00000217916; OTTHUMP00000217917; EPH homology kinase 2; EC 2.7.10.1
• Gene ID: 285220
• mRNA Refseq: NM_001080448
• Protein Refseq: NP_001073917
• MIM: 600066
• UniProt ID: B3KS12
• Chromosome Location: 3q11.2
• Function: ATP binding; ephrin receptor activity; molecular function; nucleotide binding; receptor activity