"ADRBK1" Related Products

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Recombinant Human Adrenergic, Beta, Receptor Kinase 1, GST-tagged

Cat. No.: ADRBK1-1019H
Product Overview: Full-length recombinant human ADRBK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: ADRBK1 is a ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G protein-coupled receptors. ADRBK1 phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
Applications: Kinase Assay; Western Blot
Molecular Weight: 102 kDa
Expression System: Sf9 insect cells using baculovirus
Species: Human
Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Purity: >90%
Concentration: 0.1 ug/ul
Specific Activity: 5.3 nmol/min/mg
Sequences: Full length
Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: CXCR4-mediated signaling events; Ca-dependent events; CaM pathway; Calmodulin induced events; Chemokine signaling pathway; Endocytosis; G alpha (q) signalling events; G-protein mediated events; GPCR downstream signaling; Glutamatergic synapse; Opioid Signalling; PLC beta mediated events; PLC-gamma1 signalling; Signalling by NGF; Signalling by NGF
Gene Name: ADRBK1 adrenergic, beta, receptor kinase 1 [ Homo sapiens ]
Official Symbol: ADRBK1
Synonyms: ADRBK1; adrenergic, beta, receptor kinase 1; GRK2; BARK1; FLJ16718; BETA-ARK1; beta-adrenergic receptor kinase 1; beta-ARK-1; OTTHUMP00000235171; G-protein coupled receptor kinase 2
Gene ID: 156
mRNA Refseq: NM_001619
Protein Refseq: NP_001610
MIM: 109635
UniProt ID: P25098
Chromosome Location: 11q13
Function: ATP binding; Edg-2 lysophosphatidic acid receptor binding; G-protein coupled receptor kinase activity; alpha-2A adrenergic receptor binding; beta-adrenergic receptor kinase activity; nucleotide binding; protein binding; protein kinase activity; signal transducer activity

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