Recombinant Human Adrenergic, Beta, Receptor Kinase 1, GST-tagged
Cat.No. : | ADRBK1-1019H |
Product Overview : | Full-length recombinant human ADRBK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | ADRBK1-1019H |
Description : | ADRBK1 is a ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G protein-coupled receptors. ADRBK1 phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. |
Applications : | Kinase Assay; Western Blot |
Molecular Weight : | 102 kDa |
Expression System : | Sf9 insect cells using baculovirus |
Species : | Human |
Form : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
Purity : | >90% |
Concentration : | 0.1 ug/ul |
Specific Activity : | 5.3 nmol/min/mg |
Sequences : | Full length |
Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | CXCR4-mediated signaling events; Ca-dependent events; CaM pathway; Calmodulin induced events; Chemokine signaling pathway; Endocytosis; G alpha (q) signalling events; G-protein mediated events; GPCR downstream signaling; Glutamatergic synapse; Opioid Signalling; PLC beta mediated events; PLC-gamma1 signalling; Signalling by NGF; Signalling by NGF |
Gene Name : | ADRBK1 adrenergic, beta, receptor kinase 1 [ Homo sapiens ] |
Official Symbol : | ADRBK1 |
Synonyms : | ADRBK1; adrenergic, beta, receptor kinase 1; GRK2; BARK1; FLJ16718; BETA-ARK1; beta-adrenergic receptor kinase 1; beta-ARK-1; OTTHUMP00000235171; G-protein coupled receptor kinase 2 |
Gene ID : | 156 |
mRNA Refseq : | NM_001619 |
Protein Refseq : | NP_001610 |
MIM : | 109635 |
UniProt ID : | P25098 |
Chromosome Location : | 11q13 |
Function : | ATP binding; Edg-2 lysophosphatidic acid receptor binding; G-protein coupled receptor kinase activity; alpha-2A adrenergic receptor binding; beta-adrenergic receptor kinase activity; nucleotide binding; protein binding; protein kinase activity; signal transducer activity |
Products Types
◆ Recombinant Protein | ||
ADRBK1-202R | Recombinant Rat ADRBK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ADRBK1-2437H | Recombinant Human ADRBK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ADRBK1-978H | Recombinant Human ADRBK1 protein(Met1-Leu689), His&GST-tagged | +Inquiry |
ADRBK1-383H | Active Recombinant Human ADRBK1 Protein, GST-tagged | +Inquiry |
ADRBK1-546R | Recombinant Rat ADRBK1 Protein | +Inquiry |
◆ Lysates | ||
ADRBK1-625HCL | Recombinant Human ADRBK1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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