"GRK6" Related Products


Recombinant Human G Protein-Coupled Receptor Kinase 6, GST-tagged

Cat. No. : GRK6-1020H
Product Overview : Full-length recombinant human GRK6 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : GRK6 is a Ser/Thr protein kinase and a member of the G protein-coupled receptor kinase subfamily. GRK6 is present in all tissues with strongest expression in placenta and skeletal muscle. GRK6 can phosphorylate proteins such as rhodopsin, ADRB2 and the leukotriene B4 receptor BLT1. GRK6 phosphorylates G protein-coupled dopamine receptors, thereby regulating their activity and mediating desensitization of the receptors.
Applications : Kinase Assay; Western Blot
Molecular Weight : 93 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, PH 7.5, 150 mM NaCI, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Purity : >80%
Concentration : 0.1 ug/ul
Specific Activity : 11 nmol/min/mg
Sequences : Full length
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : CXCR4-mediated signaling events; Chemokine signaling pathway; Chemokine signaling pathway; Endocytosis; Myometrial Relaxation and Contraction Pathways
PDBrendering based on 2acx. :

Gene Name : GRK6 G protein-coupled receptor kinase 6 [ Homo sapiens ]
Official Symbol : GRK6
Synonyms : GRK6; G protein-coupled receptor kinase 6; GPRK6; FLJ32135; G protein-coupled receptor kinase 6; OTTHUMP00000223834; OTTHUMP00000223835; OTTHUMP00000223836; OTTHUMP00000231482; OTTHUMP00000231483; g protein-coupled receptor kinase GRK6
Gene ID : 2870
mRNA Refseq : NM_001004105
Protein Refseq : NP_001004105
MIM : 600869
UniProt ID : P43250
Chromosome Location : 5q35
Function : ATP binding; G-protein coupled receptor kinase activity; nucleotide binding; signal transducer activity

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