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Recombinant Murine Epidermal Growth Factor

Cat.No. : Egf-05H
Product Overview : Recombinant Murine Epidermal Growth Factor produced inE. coliis a single non-glycosylated polypeptide chain containing 53 amino acids(including 3 intramolecular disulfide-bonds) and having a molecular mass of 6.0kDa.
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  • Gene Information
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Cat. No. : Egf -05H
Description : EGF was originally discovered in crude preparations of nerve growth factor prepared from mouse submaxillary glands as an activity that induced early eyelid opening, incisor eruption, hair growth inhibition, and stunting of growth when injected into newborn mice. EGF is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. Additionally, EGF has been shown to inhibit gastric secretion, and to be involved in wound healing. EGF signals through a receptor known as c-erbB, which is a class I tyrosine kinase receptor. This receptor also binds with TGF-alpha and VGF (vaccinia virus growth factor).
Purity : >97% by SDS-PAGE and HPLC analyses.
Formulation : Lyophilized from a 0.2mm filtered concentrated (1mg/ml) solution in PBS, pH 7.4.
Specific Activity : Fully biologically active when compared to standard. The ED50 as calculated by the dose-dependant proliferation of murine BALB/c 3T3 cells (measured by 3H-thymidine uptake) is less than 0.1 ng/ml.
Endotoxin : Less than 1EU/mg of rmEGF as determined by LAL method.
Reconstitutionon : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤20°C. Further dilutions should be made in appropriate buffered solutions.
Storage : This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Gene Name : Egf
Synonyms : AI790464; URG; urogastrone; Pro-epidermal growth factor precursor; epidermal growth factor; epidermal growth factor (beta-urogastrone); Egf
Gene ID : 13645
mRNA Refseq : NM_010113
Protein Refseq : NP_034243
MIM : 131530
UniProt ID : P01132
Chromosome Location : Chr 3: 129.67 - 129.75 Mb
Pathway : Cytokine-cytokine receptor interaction; Endometrial cancer; ErbB signaling pathway; Focal adhesion; Gap junction; Glioma; MAPK signaling pathway; Melanoma; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer; Regulation of actin cytoskeleton
Function : calcium ion binding; growth factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is EGF protein produced in the body? 02/07/2022

The body naturally produces EGF protein, and it can also be synthesized for clinical applications using biotechnological methods.

Are there any side effects associated with the clinical use of EGF protein? 12/06/2021

Generally, EGF is well-tolerated, but localized irritation or redness at the application site can occur in some cases.

Can EGF be used in the treatment of burns? 11/03/2021

Yes, EGF has been explored for its potential in treating burns by promoting the regeneration of damaged skin tissue.

What are the primary clinical applications of EGF protein? 10/19/2021

EGF protein is widely used in clinical settings for wound healing, tissue regeneration, and certain dermatological conditions.

Is EGF used in cosmetic products, and if so, for what purpose? 09/28/2019

Yes, EGF is a common ingredient in some cosmetic products due to its ability to promote skin rejuvenation and reduce the appearance of fine lines and wrinkles.

Customer Reviews (3)

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Reviews
01/27/2020

    This can be advantageous in understanding disease mechanisms and developing novel therapeutics.

    04/12/2018

      The manufacturer can provide detailed documentation on the quality control measures undertaken during protein production and purification.

      05/09/2016

        The manufacturer can offer technical expertise and guidance to researchers regarding the proper use, handling, and storage of EGF protein.

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