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Active Recombinant Human EGF, MIgG2a Fc-tagged

Cat.No. : EGF-550H
Product Overview : The extracellular domain of rat EGF(NP_036974.1)(Asn974-Arg1026) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell.
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Description : This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as alarge precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factorpeptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferationand differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor,epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation ofthis gene has been associated with the growth and progression of certain cancers. Alternate splicing results inmultiple transcript variants.
Source : CHO cell
Species : Human
Tag : MIgG2a Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured in a cell proliferation assay using MC/9‑2 mouse mast cells.
Molecular Mass : 32KDa (monomer)
AA Sequence : Asn974-Arg1026
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Protein length : Asn974-Arg1026
Gene Name : EGF epidermal growth factor [ Homo sapiens ]
Official Symbol : EGF
Synonyms : EGF; epidermal growth factor; epidermal growth factor (beta urogastrone); pro-epidermal growth factor; beta-urogastrone; URG; HOMG4;
Gene ID : 1950
mRNA Refseq : NM_001178130
Protein Refseq : NP_001171601
MIM : 131530
UniProt ID : P01133
Chromosome Location : 4q25
Pathway : Arf6 signaling events, organism-specific biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Ceramide signaling pathway, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem;
Function : calcium ion binding; epidermal growth factor receptor binding; growth factor activity; protein binding; transmembrane receptor protein tyrosine kinase activator activity;

Not For Human Consumption!

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01/27/2020

    This can be advantageous in understanding disease mechanisms and developing novel therapeutics.

    04/12/2018

      The manufacturer can provide detailed documentation on the quality control measures undertaken during protein production and purification.

      05/09/2016

        The manufacturer can offer technical expertise and guidance to researchers regarding the proper use, handling, and storage of EGF protein.

        Q&As (5)

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        How is EGF protein produced in the body? 02/07/2022

        The body naturally produces EGF protein, and it can also be synthesized for clinical applications using biotechnological methods.

        Are there any side effects associated with the clinical use of EGF protein? 12/06/2021

        Generally, EGF is well-tolerated, but localized irritation or redness at the application site can occur in some cases.

        Can EGF be used in the treatment of burns? 11/03/2021

        Yes, EGF has been explored for its potential in treating burns by promoting the regeneration of damaged skin tissue.

        What are the primary clinical applications of EGF protein? 10/19/2021

        EGF protein is widely used in clinical settings for wound healing, tissue regeneration, and certain dermatological conditions.

        Is EGF used in cosmetic products, and if so, for what purpose? 09/28/2019

        Yes, EGF is a common ingredient in some cosmetic products due to its ability to promote skin rejuvenation and reduce the appearance of fine lines and wrinkles.

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