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Recombinant Human Intestinal Cell (MAK-like) Kinase, GST-tagged

Cat. No.: ICK-1026H
Product Overview: Full-length recombinant human ICK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: ICK or intestinal cell kinase belongs to a very extensive family of proteins that share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. ICK encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. ICK localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. ICK purified from transfected human embryonic kidney cells undergoes autophosphorylation and phosphorylates a test protein. ICK plays a key role in development of central nervous, skeletal, and endocrine systems.
Applications: Kinase Assay; Western Blot
Molecular Weight: 98 kDa
Expression System: Sf9 insect cells using baculovirus
Species: Human
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0,25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Specific Activity: 4.8 mmol/min/mg
Purity: > 75 %
Concentration: 0.1 ug/ul
Sequences: Full-length
Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: ICK intestinal cell (MAK-like) kinase [ Homo sapiens ]
Official Symbol: ICK
Synonyms: ICK; intestinal cell (MAK-like) kinase; ECO; MRK; LCK2; KIAA0936; MGC46090; serine/threonine-protein kinase ICK; hICK; MAK-related kinase; OTTHUMP00000016630; laryngeal cancer kinase 2; serine/threonine protein kinase; NP_055735.1; EC 2.7.11.22; NP_057597.2; Laryngeal cancer kinase 2; Intestinal cell kinase; EC 2.7.11
Gene ID: 22858
mRNA Refseq: NM_014920
Protein Refseq: NP_055735
MIM: 612325
UniProt ID: Q9UPZ9
Chromosome Location: 6p12.1
Function: ATP binding; cyclin-dependent protein kinase activity; magnesium ion binding; nucleotide binding; protein serine/threonine kinase activity

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