Recombinant Human Lysine (K)-Specific Demethylase 5C, GST-tagged

• Cat.No.: KDM5C-1604H
• Product Overview: Recombinant human KDM5C (1-671) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Cat. No.: KDM5C-1604H
• Description: KDM5C or lysine (K)-specific demethylase 5C is a member of the SMCY homolog family that encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. KDM5C is mainly expressed in brain and skeletal muscle. KDM5C is involved in the regulation of transcription and chromatin remodelling that cause X-linked mental retardation. KDM5C is also essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.
• Applications: Western Blot
• Molecular Weight: 118 kDa
• Expression System: Sf9 insect cells using baculovirus.
• Species: Human
• Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
• Purity: > 80 %
• Concentration: 0.1 ug/ul
• Sequences: 1-671
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: KDM5C lysine (K)-specific demethylase 5C [ Homo sapiens ]
• Official Symbol: KDM5C
• Synonyms: KDM5C; KAM5C; MRXJ; SMCX; MRXSJ; XE169; JARID1C; DXS1272E; lysine (K)-specific demethylase 5C; Jumonji, AT rich interactive domain 1C (RBP2-like); Histone demethylase JARID1C; Protein SmcX; Jumonji/ARID domain-containing protein 1C; jumonji, AT rich interactive domain 1C; Smcy homolog, X-linked (mouse); JmjC domain-containing protein SMCX; lysine-specific demethylase 5C; selected cDNA on X; Smcx homolog, X chromosome; Smcy homolog, X-linked; EC 1.14.11.; Protein Xe169
• Gene ID: 8242
• mRNA Refseq: NM_004187
• Protein Refseq: NP_004178
• MIM: 609132
• UniProt ID: P41229
• Chromosome Location: Xp11.22-p11.21
• Function: DNA binding; metal ion binding; molecular_function; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular ; oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; zinc ion binding