"MAPKAPK3" Related Products


Recombinant Human Mitogen-activated Protein Kinase-Activated Protein Kinase 3, GST-tagged

Cat. No. : MAPKAPK3-1055H
Product Overview : Recombinant full-length human MAPKAPK3 was expressed in E. coli cells using an N-terminal GST tag.
Description : MAPKAPK3 is closely related to MAPKAPK2 sharing 72% nucleotide and 75% amino acid identity. MAPKAPK3 is activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of MAPKAPK3 as an integrative element of signaling in both mitogen and stress responses.
Applications : Kinase Assay; Western Blot
Molecular Weight : 69 kDa
Expression System : E. coli
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Purity : > 90%
Concentration : 0.2 ug/ul
Sequences : Full-length
Storage : Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Activated TLR4 signalling; FAS pathway and Stress induction of HSP regulation; Immune System; MAP kinase activation in TLR cascade; MAPK signaling pathway; MyD88 cascade initiated on plasma membrane; MyD88 dependent cascade initiated on endosom; MyD88:Mal cascade initiated on plasma membrane; NFkB and MAP kinases activation mediated by TLR4 signaling repertoire; NGF signalling via TRKA from the plasma membrane; Signaling mediated by p38-alpha and p38-beta; Signalling by NGF
Renderingbased on PDB 3FHR. :

Gene Name : MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 [ Homo sapiens ]
Official Symbol : MAPKAPK3
Synonyms : MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3; 3PK; MAPKAP3; MAPKAPK-3; MAP kinase-activated protein kinase 3; MAPKAP kinase 3; OTTHUMP00000210805; OTTHUMP00000210806; OTTHUMP00000210807; chromosome 3p kinase; MAPK-activated protein kinase 3; EC
Gene ID : 7867
mRNA Refseq : NM_004635
Protein Refseq : NP_004626
MIM : 602130
UniProt ID : Q16644
Chromosome Location : 3p21.3
Function : ATP binding; MAP kinase kinase activity; nucleotide binding; protein binding; protein serine/threonine kinase activity

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