Cat. No.:	PRMT3-1617H
Product Overview:	Recombinant full-length human PRMT3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description:	PRMT3 is a protein arginine methyltransferase that catalyze the formation of asymmetric N (G),N (G)-dimethylarginine (ADMA) residues in proteins. 40S ribosomal protein S2 is a physiological substrate of PRMT3 and PRMT3 regulates ribosome biosynthesis at a stage beyond pre-rRNA processing. DAL-1 (differentially expressed in adenocarcinoma of the lung)/4.1B is a tumor suppressor gene that can significantly inhibits PRMT3 methylation of cellular substrates. Modulation of post-translational methylation may be an important mechanism through which DAL-1/4.1B affects tumor cell growth.
Applications:	Western Blot
Molecular Weight:	97 kDa
Expression System:	Sf9 insect cells using baculovirus
Species:	Human
Form:	Recombinant protein stored in 50 mM Tris-HCL, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol, 0.1 mM EDTA.
Purity:	> 90 %
Concentration:	0.1 ug/ul
Storage:	Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Name:	PRMT3 protein arginine methyltransferase 3 [ Homo sapiens ]
Official Symbol:	PRMT3
Synonyms:	PRMT3; protein arginine methyltransferase 3; HRMT1L3; HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae); Protein arginine N-methyltransferase 3; EC 2.1.1;Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3
Gene ID:	10196
mRNA Refseq:	NM_001145166
Protein Refseq:	NP_001138638
MIM:	603190
UniProt ID:	O60678
Chromosome Location:	11p15.1
Function:	metal ion binding; protein-arginine N-methyltransferase activity; transferase activity; zinc ion binding

Online Inquiry