Recombinant Human Protein Tyrosine Phosphatase, Non-Receptor Type 12, GST-tagged

• Cat.No.: PTPN12-1620H
• Product Overview: Recombinant human PTPN12 (1-355) was expressed in E. coli cells using a N-terminal GST tag.

Specification

• Cat. No.: PTPN12-1620H
• Description: PTPN12 is thought to play an important role in cell adhesion and motility, cell migration, and signal transduction for antigen receptors in B and T lymphocytes. Signal transduction via tyrosine phosphorylation, normally fine-tuned by the concerted action of both protein tyrosine kinases and PTPs, is a key mechanism in tumorigenesis. Studies suggest potential role for PTP-PEST in regulation of p130 (cas) in mitogen and cell adhesion-induced signaling events.
• Applications: Phosphatase Assay; Western Blot
• Molecular Weight: 66 kDa
• Expression System: E. coli
• Species: Human
• Form: Recombinant protein stored in 20 mM MOPS, pH 7.5, 50 mM NaCl, 10 mM glutathione, 0.25 mM DTT, 0.1 mM PMSF, 30 % glycerol.
• Specific Activity: 2965 nmol/min/mg
• Purity: > 75 %
• Concentration: 0.1 ug/ul
• Sequences: 1-355
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: EGFR1 Signaling Pathway; T Cell Receptor Signaling Pathway

Gene Information

• Gene Name: PTPN12 protein tyrosine phosphatase, non-receptor type 12 [ Homo sapiens ]
• Official Symbol: PTPN12
• Synonyms: PTPN12; protein tyrosine phosphatase, non-receptor type 12; PTPG1; PTP-PEST; tyrosine-protein phosphatase non-receptor type 12; OTTHUMP00000161275; OTTHUMP00000208615; OTTHUMP00000208616; protein-tyrosine phosphatase G1; EC 3.1.3.48; Tyrosine-protein phosphatase non-receptor type 12; Protein-tyrosine phosphatase G1
• Gene ID: 5782
• mRNA Refseq: NM_001131008
• Protein Refseq: NP_001124480
• MIM: 600079
• UniProt ID: Q05209
• Chromosome Location: 7q11.23
• Function: SH3 domain binding; hydrolase activity; protein binding; non-membrane spanning protein tyrosine phosphatase activity