"PTPN12" Related Products


Recombinant Human Protein Tyrosine Phosphatase, Non-Receptor Type 12, GST-tagged

Cat. No.: PTPN12-1620H
Product Overview: Recombinant human PTPN12 (1-355) was expressed in E. coli cells using a N-terminal GST tag.
Description: PTPN12 is thought to play an important role in cell adhesion and motility, cell migration, and signal transduction for antigen receptors in B and T lymphocytes. Signal transduction via tyrosine phosphorylation, normally fine-tuned by the concerted action of both protein tyrosine kinases and PTPs, is a key mechanism in tumorigenesis. Studies suggest potential role for PTP-PEST in regulation of p130 (cas) in mitogen and cell adhesion-induced signaling events.
Applications: Phosphatase Assay; Western Blot
Molecular Weight: 66 kDa
Expression System: E. coli
Species: Human
Form: Recombinant protein stored in 20 mM MOPS, pH 7.5, 50 mM NaCl, 10 mM glutathione, 0.25 mM DTT, 0.1 mM PMSF, 30 % glycerol.
Specific Activity: 2965 nmol/min/mg
Purity: > 75 %
Concentration: 0.1 ug/ul
Sequences: 1-355
Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: EGFR1 Signaling Pathway; T Cell Receptor Signaling Pathway
Gene Name: PTPN12 protein tyrosine phosphatase, non-receptor type 12 [ Homo sapiens ]
Official Symbol: PTPN12
Synonyms: PTPN12; protein tyrosine phosphatase, non-receptor type 12; PTPG1; PTP-PEST; tyrosine-protein phosphatase non-receptor type 12; OTTHUMP00000161275; OTTHUMP00000208615; OTTHUMP00000208616; protein-tyrosine phosphatase G1; EC; Tyrosine-protein phosphatase non-receptor type 12; Protein-tyrosine phosphatase G1
Gene ID: 5782
mRNA Refseq: NM_001131008
Protein Refseq: NP_001124480
MIM: 600079
UniProt ID: Q05209
Chromosome Location: 7q11.23
Function: SH3 domain binding; hydrolase activity; protein binding; non-membrane spanning protein tyrosine phosphatase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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