Recombinant Human Sirtuin 6, His-tagged

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Recombinant Human Sirtuin 6, His-tagged

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Cat. No. : SIRT6-4882H
Product Overview : Recombinant human SIRT6 (23-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Description : SIRT6 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT6 being a member of class IV. Human SIRT6 protein is a NAD (+)-dependent histone H3 lysine-9 deacetylase that modulates telomeric chromatin. SIRT6 associates specifically with telomeres and SIRT6 depletion leads to telomere dysfunction with end-to-end chromosomal fusions and premature cellular senescence.
Applications : SIRT Assay
Molecular Weight : 39 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25 % glycerol.
Specific Activity : 120 RLU/min/mg
Purity : > 90 %
Concentration : 0.1 ug/ul
Sequences : 23-end
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Signaling events mediated by HDAC Class I
Gene Name : SIRT6 sirtuin 6 [ Homo sapiens ]
Official Symbol : SIRT6
Synonyms : SIRT6; sirtuin 6; SIR2L6; NAD-dependent deacetylase sirtuin-6; sirtuin type 6; SIR2-like protein 6; sir2-related protein type 6; EC 2.4.2.31; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6
Gene ID : 51548
mRNA Refseq : NM_016539
Protein Refseq : NP_057623
MIM : 606211
UniProt ID : Q8N6T7
Chromosome Location : 19p13.3
Function : NAD binding; NAD (P)+-protein-arginine ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; hydrolase activity; metal ion binding; protein binding; transferase activity, transferring glycosyl groups; zinc ion binding; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific)

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