Recombinant Human Sirtuin 6, His-tagged
Cat.No. : | SIRT6-4882H |
Product Overview : | Recombinant human SIRT6 (23-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | SIRT6-4882H |
Description : | SIRT6 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT6 being a member of class IV. Human SIRT6 protein is a NAD (+)-dependent histone H3 lysine-9 deacetylase that modulates telomeric chromatin. SIRT6 associates specifically with telomeres and SIRT6 depletion leads to telomere dysfunction with end-to-end chromosomal fusions and premature cellular senescence. |
Applications : | SIRT Assay |
Molecular Weight : | 39 kDa |
Expression System : | Sf9 insect cells using baculovirus |
Species : | Human |
Form : | Recombinant protein stored in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25 % glycerol. |
Specific Activity : | 120 RLU/min/mg |
Purity : | > 90 % |
Concentration : | 0.1 ug/ul |
Sequences : | 23-end |
Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | Signaling events mediated by HDAC Class I |
Gene Name : | SIRT6 sirtuin 6 [ Homo sapiens ] |
Official Symbol : | SIRT6 |
Synonyms : | SIRT6; sirtuin 6; SIR2L6; NAD-dependent deacetylase sirtuin-6; sirtuin type 6; SIR2-like protein 6; sir2-related protein type 6; EC 2.4.2.31; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6 |
Gene ID : | 51548 |
mRNA Refseq : | NM_016539 |
Protein Refseq : | NP_057623 |
MIM : | 606211 |
UniProt ID : | Q8N6T7 |
Chromosome Location : | 19p13.3 |
Function : | NAD binding; NAD (P)+-protein-arginine ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; hydrolase activity; metal ion binding; protein binding; transferase activity, transferring glycosyl groups; zinc ion binding; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific) |
Products Types
◆ Recombinant Protein | ||
SIRT6-28517H | Active Recombinant Human SIRT6 Protein, GST-tagged | +Inquiry |
SIRT6-24H | Recombinant Human SIRT6 Protein, His-tagged | +Inquiry |
Sirt6-5885M | Recombinant Mouse Sirt6 Protein, Myc/DDK-tagged | +Inquiry |
SIRT6-2691H | Recombinant Human SIRT6 Protein, His-tagged | +Inquiry |
SIRT6-121H | Recombinant Human SIRT6 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
SIRT6-1829HCL | Recombinant Human SIRT6 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2341 | SIRT6 Inhibitor Screening Kit (Fluorometric) | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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