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Recombinant Human SET And MYND Domain Containing 2, GST-tagged

Cat.No. : SMYD2-1633H
Product Overview : Recombinant full-length human SMYD2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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Cat. No. : SMYD2-1633H
Description : SMYD2 (also known as SET and MYND domain-containing protein 2) is a member of the SMYD family of protein methyltransferases. SMYD2 is also known as lysine methyltransferase protein 3C (KMT3C). SMYD2 functions to repress transcription by interacting with the Sin3A histone deacetylase complex and performs methylation of Lys36 in histone H3. The exogenous expression of SMYD2 in mouse fibroblasts decreases cell growth. SMYD2 also function as a putative oncogene by methylating p53 and repressing its tumor suppressive function.
Applications : Western Blot
Molecular Weight : 70 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCL, pH 7.5, 150 mM NaCl, 0.1 mM PMSF, 0.25 mM DTT, 10 mM gluthione, 0.1 mM EDTA, 25 % glycerol.
Purity : > 85 %
Concentration : 0.1 ug/ul
Sequences : Full-length
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : SMYD2 SET and MYND domain containing 2 [ Homo sapiens ]
Official Symbol : SMYD2
Synonyms : SMYD2; SET and MYND domain containing 2; KMT3C; HSKM-B; ZMYND14; MGC119305; zinc finger, MYND domain containing 14; OTTHUMP00000035134; Lysine N-methyltransferase 3C
Gene ID : 56950
mRNA Refseq : NM_020197
Protein Refseq : NP_064582
MIM : 610663
UniProt ID : Q9NRG4
Chromosome Location : 1q32.3-q41
Function : metal ion binding; protein binding; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any drugs targeting SMYD2 in the clinical pipeline? 07/30/2020

Investigations into small molecules and inhibitors targeting SMYD2 are underway, with potential applications in cancer and cardiovascular disease treatment.

In what ways can SMYD2 be utilized in the diagnosis of cardiovascular disorders? 06/29/2020

Monitoring SMYD2 levels may provide insights into the progression of cardiovascular diseases, aiding in early diagnosis and treatment.

Can SMYD2 be used as a therapeutic target for neurodegenerative disorders? 03/26/2020

Research suggests that SMYD2 may play a role in neurodegenerative diseases, and exploring its modulation could offer new avenues for therapeutic intervention.

How does SMYD2 influence cellular processes beyond cancer and cardiac diseases? 07/15/2018

SMYD2 is involved in various cellular processes, including cell cycle regulation, DNA repair, and inflammation, making it a versatile protein with potential implications in multiple diseases.

How does SMYD2 contribute to cardiac disease? 10/05/2016

SMYD2 has been linked to cardiac hypertrophy and heart failure, suggesting its potential as a therapeutic target in the context of cardiovascular diseases.

Customer Reviews (3)

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Reviews
01/16/2018

    Its compatibility with various methodologies further enhances its value as a research tool, making it a go-to choice for investigating SMYD2 protein function and molecular interactions.

    03/20/2017

      The versatility of the SMYD2 protein extends beyond these applications, enabling its use in a wide range of experimental techniques.

      08/31/2016

        the SMYD2 protein stands out for its exceptional quality and its ability to fulfill my experimental requirements.

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