"TNNI1" Related Products


Recombinant Human TNNI1 protein, His-tagged

Cat.No.: TNNI1-4836H
Product Overview: Recombinant Human TNNI1 fused with His tag at N-terminal was expressed in E. coli.
Description: Troponin1 is a member of the tropomyosin family and regulates the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin1 is part of a complex with troponin T and troponin C in which Troponin1 acts as an inhibitory subunit that blocks actin-myosin interactions and thereby mediates striated muscle relaxation. Troponin1 is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The Troponin1 protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.
Source: E. coli
Species: Human
Tag: His
Form: 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Molecular Mass: ~24 kDa
Purity: >75%
Applications: Western Blot
Stability: 1year at - 70 centigrade from date of shipment
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.2 μg/μl
Gene Name: TNNI1 troponin I type 1 (skeletal, slow) [ Homo sapiens ]
Official Symbol: TNNI1
Synonyms: TNNI1; troponin I type 1 (skeletal, slow); troponin I, skeletal, slow; troponin I, slow skeletal muscle; troponin I, slow-twitch isoform; TNN1; SSTNI; DKFZp451O223;
Gene ID: 7135
mRNA Refseq: NM_003281
Protein Refseq: NP_003272
MIM: 191042
UniProt ID: P19237
Chromosome Location: 1q31.3
Pathway: Muscle contraction, organism-specific biosystem; Striated Muscle Contraction, organism-specific biosystem; Striated Muscle Contraction, organism-specific biosystem;
Function: actin binding; tropomyosin binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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