Recombinant Human Dual Specificity Phosphatase 19, His-tagged

• Cat.No.: DUSP19-1317H
• Product Overview: Recombinant human DUSP19 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: DUSP19 is a member of the dual specificity protein phosphatase subfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 is a protein phosphatase which functions as a stress-activated protein kinase pathway-regulating phosphatase. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP class of DUSPs.
• Form: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 10% glycerol, 0.1 M NaCl.
• Molecular Weight: 9.4 kDa (176 aa), confirmed by MALDI-TOF
• Purity: > 90 % by SDS-PAGE
• Concentration: 0.5 mg/ml (determined by Bradford assay)
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MGSQVGVIKP WLLLGSQDAA HDLDTLKKNK VTHILNVAYG VENAFLSDFT YKSISILDLP ETNILSYFPE CFEFIEEAKR KDGVVLVHCN AGVSRAAAIV IGFLMNSEQT SFTSAFSLVK NARPSICPNS GFMEQLRTYQ EGKESNKCDR IQENSS
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: DUSP19 dual specificity phosphatase 19 [ Homo sapiens ]
• Official Symbol: DUSP19
• Synonyms: DUSP19; dual specificity phosphatase 19; SKRP1; DUSP17; LMWDSP3; TS-DSP1; MGC138210; dual specificity protein phosphatase 19; LMW-DSP3; OTTHUMP00000163459; OTTHUMP00000205371; protein phosphatase SKRP1; dual specificity phosphatase TS-DSP1; SAPK pathway-regulating phosphatase 1; low molecular weight dual specificity phosphatase 3; stress-activated protein kinase pathway-regulating phosphatase 1; NP_001135786.1; EC 3.1.3.16; EC 3.1.3.48
• Gene ID: 142679
• mRNA Refseq: NM_001142314
• Protein Refseq: NP_001135786
• MIM: 611437
• UniProt ID: Q8WTR2
• Chromosome Location: 2q32.1
• Function: JUN kinase phosphatase activity; MAP-kinase scaffold activity; hydrolase activity; mitogen-activated protein kinase kinase kinase binding; protein kinase activator activity; protein tyrosine phosphatase activity