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Recombinant Human Proteasome (prosome, macropain) Subunit, Beta Type, 2, His-tagged

Cat.No. : PSMB2-1321H
Product Overview : Recombinant human PSMB2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
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Cat. No. : PSMB2-1321H
Description : PSMB2 is a member of the proteasome T1B family, which is a 20S core beta subunit. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.
Form : Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 30% glycerol, 0.1 M NaCl.
Molecular Weight : 24.9 kDa (221 aa) confirmed by MALDI-TOF
Purity : >90 % by SDS-PAGE
Concentration : 0.5 mg/ml (determined by Bradford assay)
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MEYLIGIQGP DYVLVASDRV AASNIVQMKD DHDKMFKMSE KILLLCVGEA GDTVQFAEYI QKNVQLYKMR NGYELSPTAA ANFTRRNLAD CLRSRTPYHV NLLLAGYDEH EGPALYYMDY LAALAKAPFA AHGYGAFLTL SILDRYYTPT ISRERAVELL RKCLEELQKR FILNLPTFSV RIIDKNGIHD LDNISFPKQG S
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways : APC/C-mediated degradation of cell cycle proteins; Adaptive Immunity Signaling; Antigen processing; Apoptosis; Assembly of the pre-replicative complex; Autodegradation of the E3 ubiquitin ligase COP1; Cell Cycle Checkpoints; DNA Replication; G1/S DNA Damage Checkpoints; HIV Infection; G1/S Transition; Immune System; Immunoproteasome; Metabolism of RNA
Gene Name : PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 [ Homo sapiens ]
Official Symbol : PSMB2
Synonyms : PSMB2; proteasome (prosome, macropain) subunit, beta type, 2; HC7-I; MGC104215; MGC126885; proteasome subunit beta type-2; OTTHUMP00000004345; macropain subunit C7-I; proteasome beta 2 subunit; proteasome component C7-I; proteasome subunit, beta type, 2; multicatalytic endopeptidase complex subunit C7-1; multicatalytic endopeptidase complex subunit C7-I; NP_001186708.1; EC 3.4.25.1
Gene ID : 5690
mRNA Refseq : NM_001199779
Protein Refseq : NP_001186708
MIM : 602175
UniProt ID : Q59FJ0
Chromosome Location : 1p34.2
Function : peptidase activity; threonine-type endopeptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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