Recombinant Human Transcription Elongation Factor B (SIII), Polypeptide 1 (15kDa, elongin C), His-tagged
Cat.No. : | TCEB1-4832H |
Product Overview : | Recombinant human TCEB1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
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Cat. No. : | TCEB1-4832H |
Description : | TCEB1 (elongin C) is a subunit of elongin, which is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template encoded arresting sites. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau(VHL) tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing10% glycerol, 1mM DTT, 0.15M NaCl. |
Molecular Weight : | 14.6 kDa (132aa), confirmed by MALDI-TOF. |
Purity : | >90% by SDS-PAGE |
Concentration : | 1 mg/ml (determined by Bradford) |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MDGEEKTYGG CEGPDAMYVK LISSDGHEFI VKREHALTSG TIKAMLSGPG QFAENETNEV NFREIPSHVL SKVCMYFTYK VRYTNSSTEI PEFPIAPEIA LELLMAANFL DC |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Pathways : | Adaptive Immunity Signaling; Antigen processing: Ubiquitination& Proteasome degradation; Class I MHC mediated antigen processing & presentation; ECS complex; ECV complex; Formation and Maturation of mRNA Transcript; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of HIV-1 elongation complex in the absence of HIV-1 Tat; Formation of RNA Pol II elongation complex; Gene Expression; HIF-2-alpha transcription factor network; HIV Infection; HIV Life Cycle; HIV-1 Transcription Elongation; HIV-1 elongation arrest and recovery |
Gene Name : | TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) [ Homo sapiens ] |
Official Symbol : | TCEB1 |
Synonyms : | TCEB1; transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); SIII; transcription elongation factor B polypeptide 1; eloC; SIII p15; elongin-C; OTTHUMP00000226846; OTTHUMP00000226847; OTTHUMP00000226848; OTTHUMP00000226849; OTTHUMP00000226850; OTTHUMP00000226851; OTTHUMP00000226852; OTTHUMP00000227658; elongin 15 kDa subunit; transcription elongation factor B, polypeptide 1; RNA polymerase II transcription factor SIII subunit C; Elongin 15 kDa subunit; transcription elongation factor B polypeptide 1; EloC; transcription elongation factor B (SIII), polypeptide 1 (15kD, elongin C); Elongin-C |
Gene ID : | 6921 |
mRNA Refseq : | NM_001204857 |
Protein Refseq : | NP_001191786 |
MIM : | 600788 |
UniProt ID : | Q15369 |
Chromosome Location : | 8q21.11 |
Function : | protein binding |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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