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Active Recombinant Human Endostatin

Cat.No. : COL18A1-19H
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  • Gene Information
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ProductOverview : Recombinant HumanEndostatin produced in E. coliis a single glycosylated polypeptide having a total molecular mass of 20 kDa.
Description : Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexinfamilyEndostatin specifically inhibits proliferation of endothelial cells although it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes. Recombinant Endosatin expressed in yeast causes G1 arrest of endothelial cells, and endostatin treatment results in apoptosis of HUVE and HMVE cells.
Species : Human
Source : E. coli
Form : Lyophilized from a 0.2μm filtered concentrated (1mg/ml) solution in PBS, pH 7.4.
Purity : >96% by SDS-PAGE and HPLC analyses.
Bio-activity : Fully biologically active when compared to standard. The activity calculated by ECE migration inhibition was found to be 50,000IU/mg.
EndotoxinLevel : Less than 1EU/μg of rHuEndostatin as determined by LAL method.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20oC. Further dilutions should be made in appropriate buffered solutions.
Storage : Store it under sterile conditions at -20 ~ -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : COL18A1 collagen, type XVIII, alpha 1 [ Homo sapiens ]
Official Symbol : COL18A1
Synonyms : FLJ27325; KNO; KNO1; MGC74745; OTTHUMP00000115472; OTTHUMP00000115473; alpha 1 type XVIII collagen; antiangiogenic agent; endostatin; multi-functional protein MFP; XVIII chain precursor; Collagen alpha-1; XVIIIchain precursor; collagen, type XVIII, alpha 1; human type XVIII collagen; COL18A1
Gene ID : 80781
mRNA Refseq : NM_030582
Protein Refseq : NP_085059
MIM : 120328
UniProt ID : P39060
Chromosome Location : 21q22.3
Function : binding, extracellular matrix structural constituent, metal ion binding, protein binding, structural molecular activity, zinc ion binding.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can you discuss the role of COL18A1 in neurobiology, particularly its involvement in the central nervous system and potential implications for neurodegenerative disorders? 04/16/2021

COL18A1 has roles in the central nervous system. Understanding its functions provides insights into potential implications for neurodegenerative disorders and neural tissue development.

In angiogenesis, how does COL18A1 influence blood vessel formation, and what molecular mechanisms are involved in its regulation of endothelial cell behavior? 06/02/2020

COL18A1 plays a role in angiogenesis by regulating endothelial cell behavior. It interacts with integrins and growth factors, influencing signaling pathways essential for blood vessel formation.

What evidence supports the involvement of COL18A1 mutations in human diseases, and how do these mutations impact COL18A1 function and tissue homeostasis? 01/19/2019

Mutations in COL18A1 are associated with various diseases. Understanding the impact of these mutations on collagen XVIII function provides insights into their roles in tissue homeostasis and disease pathology.

How does COL18A1 contribute to the regulation of cellular senescence, and are there implications for age-related diseases and tissue degeneration? 12/30/2018

COL18A1 has been implicated in the regulation of cellular senescence. Understanding its role in age-related diseases may provide insights into tissue degeneration and potential therapeutic targets.

In cancer progression, how does COL18A1 influence tumor behavior, metastasis, and interactions with the tumor microenvironment? 08/11/2018

COL18A1 is implicated in cancer progression, affecting tumor behavior and metastasis. Its interactions within the tumor microenvironment contribute to the regulation of invasive phenotypes.

Customer Reviews (3)

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Reviews
06/01/2022

    The delivery was well-coordinated and timely.

    09/12/2019

      Superior quality resonates in this lab product, supported by customer service that is genuinely helpful.

      12/23/2018

        The lab product showcases commendable quality.

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