Active Recombinant Mouse Granzyme
Cat.No. : | Gzmb-1693M |
Product Overview : | Recombinant Mouse Gzmb protein, was expressed in Baculovirus and purified by using conventional chromatography. |
- Specification
- Gene Information
- Related Products
Cat. No. : | Gzmb-1693M |
Description : | Granzyme B is a cysteine protease found in the cytoplasmic granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme B is required for the induction of target cell lysis, which occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms. Proteolytic cleavage of substrates by Granzyme B takes place primarily after aspartic acid residues. |
Source : | Mouse |
Host : | Baculovirus |
Form : | Supplied as a lyophilized powder. |
Purity : | > 98% by SDS - PAGE |
Sequence : | Region of Granzyme B protein corresponding to amino acids IIGGHEVKPH SRPYMALLSI KDQQPEAICG GFLIREDFVL TAAHCEGSII NVTLGAHNIK EQEKTQQVIP MVKCIPHPDY NPKTFSNDIM LLKLKSKAKR TRAVRPLNLP RRNVNVKPGD VCYVAGWGRM APMGKYSNTL QEVELTVQKD RECESYFKNR YNKTNQICAG DPKTKRASFR |
Molecular Mass : | 28.9 kDa |
Applications : | Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions |
Endotoxin Levels : | Endotoxin level is less than 0.1 ng per ug (1 EU/ug). |
Bioactivity : | Determined by its ability to cleave a synthetic chromogentic Granzyme B substrate. The expected specific activity, when using the Ac-IEPD-pNA substrate at 250C, is greater than 750 nM/min per ug of enzyme. |
Storage : | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
Gene Name : | Gzmb granzyme B [ Mus musculus ] |
Official Symbol : | Gzmb |
Synonyms : | Gzmb; granzyme B; GZB; CCP1; Ctla1; Ctla-1; AI553453; CCP-1/C11; EC 3.4.21.79 |
Gene ID : | 14939 |
mRNA Refseq : | NM_013542 |
Protein Refseq : | NP_038570 |
UniProt ID : | P04187 |
Chromosome Location : | 14 D3; 14 20.5 cM |
Pathway : | Allograft rejection; Autoimmune thyroid disease; Graft-versus-host disease; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus |
Function : | hydrolase activity; peptidase activity; protein binding; serine-type endopeptidase activity; serine-type peptidase activity |
Products Types
◆ Recombinant Protein | ||
GZMB-3093H | Recombinant Human GZMB Protein, His (Fc)-Avi-tagged | +Inquiry |
Gzmb-2516M | Recombinant Mouse Gzmb Protein | +Inquiry |
Gzmb-4025M | Recombinant Mouse Gzmb Protein, His (Fc)-Avi-tagged | +Inquiry |
Gzmb-070M | Active Recombinant Mouse Gzmb Protein | +Inquiry |
Gzmb-4520M | Recombinant Mouse Gzmb Protein | +Inquiry |
◆ Lysates | ||
GZMB-2944HCL | Recombinant Human GZMB cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0403 | GZMB Activity Fluorometric Assay Kit | +Inquiry |
Kit-0404 | GZMB Assay/Inhibitor Screening Fluorometric Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionGZMB may be used in the development of targeted therapies for viral infections and various immune-related disorders.
GZMB can be used in cancer immunotherapy to target and eliminate cancer cells.
One challenge is to ensure that GZMB selectively targets cancer cells without causing harm to healthy cells.
GZMB-based therapies can be used against various types of cancer, including leukemia, lymphoma, and solid tumors.
GZMB's role in autoimmune diseases is complex. It can contribute to tissue damage in some autoimmune conditions, but its use in treatment is not common.
Customer Reviews (3)
Write a reviewI am delighted to express my complete satisfaction with the quality of GZMB protein, as it precisely suits my experimental requirements.
Their knowledgeable team has been readily available to address any concerns or queries, providing effective solutions and guidance whenever needed.
I have full confidence in the GZMB protein and the exceptional support provided by the manufacturer, making it my top recommendation for researchers seeking a high-quality protein for their experimental needs.
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