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Recombinant Mouse Granzyme

Cat. No.: Gzmb-1693M
Product Overview: Recombinant Mouse Gzmb protein, was expressed in Baculovirus and purified by using conventional chromatography.
Description: Granzyme B is a cysteine protease found in the cytoplasmic granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme B is required for the induction of target cell lysis, which occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms. Proteolytic cleavage of substrates by Granzyme B takes place primarily after aspartic acid residues.
Source: Mouse
Host: Baculovirus
Form: Supplied as a lyophilized powder.
Purity: > 98% by SDS - PAGE
Sequence: Region of Granzyme B protein corresponding to amino acids IIGGHEVKPH SRPYMALLSI KDQQPEAICG GFLIREDFVL TAAHCEGSII NVTLGAHNIK EQEKTQQVIP MVKCIPHPDY NPKTFSNDIM LLKLKSKAKR TRAVRPLNLP RRNVNVKPGD VCYVAGWGRM APMGKYSNTL QEVELTVQKD RECESYFKNR YNKTNQICAG DPKTKRASFR
Molecular Mass: 28.9 kDa
Applications: Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Bioactivity: Determined by its ability to cleave a synthetic chromogentic Granzyme B substrate. The expected specific activity, when using the Ac-IEPD-pNA substrate at 250C, is greater than 750 nM/min per ug of enzyme.
Storage: Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name: Gzmb granzyme B [ Mus musculus ]
Official Symbol: Gzmb
Synonyms: Gzmb; granzyme B; GZB; CCP1; Ctla1; Ctla-1; AI553453; CCP-1/C11; EC 3.4.21.79
Gene ID: 14939
mRNA Refseq: NM_013542
Protein Refseq: NP_038570
UniProt ID: P04187
Chromosome Location: 14 D3; 14 20.5 cM
Pathway: Allograft rejection; Autoimmune thyroid disease; Graft-versus-host disease; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus
Function: hydrolase activity; peptidase activity; protein binding; serine-type endopeptidase activity; serine-type peptidase activity

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