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Recombinant Human 4-Hydroxyphenylpyruvate Dioxygenase, His-tagged

Cat.No. : HPD-1705H
Product Overview : Recombinant human HPD protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
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  • Gene Information
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Cat. No. : HPD-1705H
Description : 4-hydroxyphenylpyruvate dioxygenase isoform 1, also known as HPD, is an Fe-containing enzyme, that catalyzes the second reaction in the catabolism of tyrosine the conversion of 4-hydroxyphenylpyruvate to homogentisate. Existing as a homodimer, HPD uses zinc as a cofactor to catalyze the third step in the conversion of L-phenylalanine to fumarate and acetoacetic acid. Defects in the gene encoding HPD are the cause of tyrosinemia type 3 and hawkinsinuria, both of which are inborn errors of metabolism that are associated with a variety of symptoms, including mental retardation and seizures and hair and urine abnormalities.
Concentration : 1 mg/ml
Source : Human
Host : E.coli
Form : Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, 20% glycerol and 50mM NaCl.
Purity : > 90% by SDS - PAGE
Sequence : 1-393 amino acids: MGSSHHHHHH SSGLVPRGSH MTTYSDKGAK PERGRFLHFH SVTFWVGNAK QAASFYCSKM GFEPLAYRGL ETGSREVVSH VIKQGKIVFV LSSALNPWNK EMGDHLVKHG DGVKDIAFEV EDCDYIVQKA RERGAKIMRE PWVEQDKFGK VKFAVLQTYG DTTHTLVEKM NYIGQFLPGY EAPAFMDPLL PKLPKCSLEM IDHIVGNQPD QEMV
Molecular Mass : 47 kDa (413aa) confirmed by MALDI-TOF
Applications : SDS-PAGE
Storage : Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name : HPD 4-hydroxyphenylpyruvate dioxygenase [ Homo sapiens ]
Official Symbol : HPD
Synonyms : HPD; 4-hydroxyphenylpyruvate dioxygenase; PPD; 4HPPD; GLOD3; 4-HPPD; HPPDASE; glyoxalase domain containing 3; 4-hydroxyphenylpyruvic acid oxidase; EC 1.13.11.27
Gene ID : 3242
mRNA Refseq : NM_001171993
Protein Refseq : NP_001165464
MIM : 609695
UniProt ID : P32754
Chromosome Location : 12q24-qter
Pathway : Metabolic pathways; Phenylalanine metabolism; Tyrosine metabolism; Ubiquinone and other terpenoid-quinone biosynthesis
Function : 4-hydroxyphenylpyruvate dioxygenase activity; metal ion binding; oxidoreductase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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