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Recombinant Human Interleukin 1, Beta

Cat. No.: IL1B-02H
Product Overview: Recombinant Human IL-1 beta produced inE.coliis a single non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of approximately 17.3 kDa.
Description: IL-1 beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine.
Purity: >98% by SDS-PAGE and HPLC analyses.
Formulation: Lyophilized from a 0.2mm filtered concentrated (1.0mg/ml) solution in PBS, pH 7.5.
Specific Activity: Fully biologically active when compared to standard. The ED50 as determined by the dose-dependant stimulation of murine D10S cells is less than 1.0 pg/ml, corresponding to a Specific Activity of 1.0 x 109IU/mg.
Endotoxin: Less than 1EU/mg of rHuIL-1β as determined by LAL method.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at<-20oC. Further dilutions should be made in appropriate buffered solutions.
Storage: This lyophilized preparation is stable at 2-8oC, but should be kept at -20oC for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8oC. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20oC to -70oC. Avoid repeated freeze/thaw cycles.
Gene Name: IL1B
Synonyms: IL-1; IL1F2; IL1-BETA; Catabolin; IL-1B; pro-interleukin-1-beta; Interleukin-1 beta precursor; interleukin 1, beta; preinterleukin 1 beta; IL1B_HUMAN.
Gene ID: 3553
mRNA Refseq: NM_000576
Protein Refseq: NP_000567
MIM: 147720
UniProt ID: P01584
Chromosome Location: 2q14
Pathway: Alzheimer"s disease; Apoptosis; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; MAPK signaling pathway; Toll-like receptor signaling pathway; Type I diabetes mellitus.
Function: interleukin-1 receptor binding;protein binding;signal transducer activity

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