"IL4" Related Products

Recombinant Murine Interleukin-4

Cat. No.: Il4-11M
Product Overview: Recombinant murine IL-4 produced inE.coliis a 13.5kDa globular protein containing 120 amino acid residues.
Description: IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and alergy.
Purity: >95% as determined by SDS-PAGE.
Formulation: Sterile filtered lyophilized powder
Specific Activity: The ED50 was determined by the dose-dependent proliferation of murine HT-2 cells is < 2.0ng/ml, corresponding to a specific activity of > 5 x 105IU/mg.
Endotoxin: Less than 0.1ng/µg (1 IEU/µg) determined by LAL test.
Reconstitution: It is recommended to reconstitute the lyophilized rmIL-4 in sterile 18MΩ-H2O containing at least 0.1% human serum albumin or bovine serum albumin to prepare a stock solution of no less than 5μg/ml of the cytokine.
Storage: Lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted murine IL-4 should be stored in working aliquots at -20°C. Aliquot to avoid repeated freeze-thaw cycles.
Gene Name: Il4
Synonyms: BSF1; IL-4; BCGF1; BCGF-1; MGC79402; BCGF, BCDF, B cell stimulating factor 1, Lymphocyte stimulatory factor 1, Binetrakin, Pitrakinra, Interleukin-4, IGG1 induction factor, B-cell IgG differentiation factor; Interleukin-4 Precursor; IL-4;BSF-1;B-cell growth factor 1
Gene ID: 16189
mRNA Refseq: NM_021283
Protein Refseq: NP_067258
UniProt ID: Q5SV00; P07750
Chromosome Location: 11 B1.3; 11 29.0 cM
Pathway: Cytokine-cytokine receptor interaction ; Fc epsilon RI signaling pathway ; Hematopoietic cell lineage ; Jak-STAT signaling pathway ; T cell receptor signaling pathway
Function: interleukin-4 receptor binding; protein binding

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