"IL8" Related Products

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Recombinant Human Interleukin-8 (8-79)

Cat. No.: IL8-15H
Product Overview: Recombinant Human IL-8 (8-79) produced in E. coli is a single, non-glycosylated polypeptide chain containing 72 amino acids and having a molecular mass of 8452 Dalton.
Description: Interleukin-8 (IL-8) belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 levels are associated with the onset of a variety of disease states.
Purity: >95% as determined by RP-HPLC and SDS-PAGE.
Formulation: Lyophilized from a concentrated (1mg/ml) solution containing 20mM PBS pH-7.4 and 50mM sodium chloride.
Specific Activity: rHuIL-8 /72 is fully biologically active when compared to standard. The ED50 as determined by its chemotaxis of hCXCR-2 transfected mouse BaF/3 cells is less than 2 ng/ml, corresponding to a Specific Activity of 5.0 x 105IU/mg.
Endotoxin: Less than 0.1ng/µg (1 IEU/µg) determined by LAL test.
Reconstitution: It is recommended to reconstitute the lyophilized rHuIL-8 /72 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Storage: Lyophilized rHuIL-8 /72 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHuIL-8 /72 should be stored at 4°C between 2-7 days and for future use below -18°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Aliquot to avoid repeated freeze-thaw cycles.
Gene Name: IL8
Synonyms: 3-10C; AMCF-I; CXCL8; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; T-cell chemotactic factor; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; Granulocyte chemotactic protein 1; Monocyte-derived neutrophil-activating peptide; MONAP; Emoctakin; K60; NAF; LECT; LUCT; LYNAP; SCYB8; TSG-1; b-ENAP; GCP1; IL-8; NAP1; C-X-C motif chemokine 8; Interleukin-8 precursor; beta-thromboglobulin-like protein; chemokine (C-X-C motif) ligand 8; lymphocyte-derived neutrophil-activating factor; small inducible cytokine subfamily B member 8; IL8; interleukin 8
Gene ID: 3576
mRNA Refseq: NM_000584
Protein Refseq: NP_000575
MIM: 146930
UniProt ID: P10145
Chromosome Location: 4q13-q21
Pathway: Cytokine-cytokine receptor interaction; Epithelial cell signaling in Helicobacter pylori infection; Leukocyte transendothelial migration; Toll-like receptor signaling pathway
Function: chemokine activity; interleukin-8 receptor binding; protein binding

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