Recombinant Human Glia Maturation Factor beta GMFB-04H

Recombinant Human Glia Maturation Factor beta

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Recombinant Human Glia Maturation Factor beta

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Cat. No. : GMFB-04H
Product Overview : Recombinant Human Glia Maturation Factor beta produced in E.coli is a single non-glycosylated polypeptide chain containing 141 amino acids and having a molecular mass of approximately 16.5KDa.
Description : GMF-β, a brain-specific protein that belongs to the actin-binding proteins (ADF) structural family. GMF-β appears to play a role in the differentiation, maintenance, and regeneration of the nervous system. It also supports the progression of certain auto-immune diseases, possibly through its ability to induce the production and secretion of various pro-inflammatory cytokines.
Purity : >98% by SDS-PAGE and HPLC analyses.
Formulation : Lyophilized from a 0.2mm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 130mM NaCl.
Biological Activity : The biological activity was determined by the does-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors yielding an ED50 <0.5ng/ml.
Endotoxin : Less than 1EU/μg of rHuGMF-β as determined by LAL method.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Storage : This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
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Gene Name : GMFB
Synonyms : GMF, GMF-beta, Glia maturation factor beta; glia maturation factor, beta; GMFB
Gene ID : 2764
mRNA Refseq : NM_004124.2
Protein Refseq : NP_004115.1
MIM : 601713
UniProt ID : P60983
Chromosome Location : 14q22.2
Function : actin binding, enzyme activator activity, growth factor activity, protein kinase inhibitor activity, signal transducer activity.

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