Recombinant Human Glia Maturation Factor beta


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Recombinant Human Glia Maturation Factor beta

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Cat. No. : GMFB-04H
Product Overview : Recombinant Human Glia Maturation Factor beta produced in E.coli is a single non-glycosylated polypeptide chain containing 141 amino acids and having a molecular mass of approximately 16.5KDa.
Description : GMF-β, a brain-specific protein that belongs to the actin-binding proteins (ADF) structural family. GMF-β appears to play a role in the differentiation, maintenance, and regeneration of the nervous system. It also supports the progression of certain auto-immune diseases, possibly through its ability to induce the production and secretion of various pro-inflammatory cytokines.
Purity : >98% by SDS-PAGE and HPLC analyses.
Formulation : Lyophilized from a 0.2mm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 130mM NaCl.
Biological Activity : The biological activity was determined by the does-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors yielding an ED50 <0.5ng/ml.
Endotoxin : Less than 1EU/μg of rHuGMF-β as determined by LAL method.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Storage : This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.

Gene Name : GMFB
Synonyms : GMF, GMF-beta, Glia maturation factor beta; glia maturation factor, beta; GMFB
Gene ID : 2764
mRNA Refseq : NM_004124.2
Protein Refseq : NP_004115.1
MIM : 601713
UniProt ID : P60983
Chromosome Location : 14q22.2
Function : actin binding, enzyme activator activity, growth factor activity, protein kinase inhibitor activity, signal transducer activity.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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