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Recombinant Human CPB1, His-tagged

Cat.No.: CPB1-7752H
Product Overview: Recombinant Human Carboxypeptidase B/CPB1 is produced with our mammalian cells expression system in HEK293. The target protein is expressed with sequence (His16Tyr417) of Human CPB1 fused with a polyhistidine tag at the Cterminus.
Description: Carboxypeptidase B1 is an exopeptidase which specifically cleaves the Cterminal Arg and Lys residues with a preference for Arg. Expressed mainly in pancreas, CPB1 is a useful serum marker for acute pancreatitis and pancreatic graft rejection.Human CPB1 consists of a signal peptide, a pro region, and a mature chain. The purified rhCPB1 corresponds to the pro form, which can be activated by trypsin, the only pancreatic protease capable of generating active enzyme from the zymogen in vitro.
Source: HEK293 Cells
Species: Human
Tag: His
Form: Supplied as a 0.2 μM filtered solution of 20mM MES, 150mM NaCl, pH 5.5
AA Sequence: HHGGEHFEGE KVFRVNVEDE NHINIIRELA STTQIDFWKP DSVTQIKPHS TVDFRVKAED TVTVENVLK QNELQYKVLI SNLRNVVEAQ FDSRVRATGH SYEKYNKWET IEAWTQQVAT E NPALISRS VIGTTFEGRA IYLLKVGKAG QNKPAIFMDC GFHAREWISP AFCQWFVREA VR TYGREIQ VTELLDKLDF YVLPVLNIDG YIYTWTKSRF WRKTRSTHTG SSCIGTDPNR NFD AGWCEI GASRNPCDET
Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Notes: For research use only.
Storage: Store at less than 20°C. stable for 6 months after receipt.Please minimize freezethaw cycles.
Gene Name: CPB1 carboxypeptidase B1 (tissue) [ Homo sapiens ]
Official Symbol: CPB1
Synonyms: CPB1; carboxypeptidase B1 (tissue); carboxypeptidase B; pancreatic carboxypeptidase B; protaminase; tissue carboxypeptidase B; procarboxypeptidase B; pancreas-specific protein; CPB; PASP; PCPB; DKFZp779K1333;
Gene ID: 1360
mRNA Refseq: NM_001871
Protein Refseq: NP_001862
MIM: 114852
UniProt ID: P15086
Chromosome Location: 3q24
Pathway: Pancreatic secretion, organism-specific biosystem; Pancreatic secretion, conserved biosystem; Protein digestion and absorption, organism-specific biosystem; Protein digestion and absorption, conserved biosystem;
Function: carboxypeptidase activity; metal ion binding; metallocarboxypeptidase activity; metallopeptidase activity; peptidase activity; zinc ion binding;

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