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Recombinant Human CLEC4E, His-tagged

Cat.No.: CLEC4E-7776H
Product Overview: Recombinant Human CType Lectin Domain Family 4 Member E/CLEC4E is produced with our mammalian cells expression system in HEK293. The target protein is expressed with sequence (Arg41Leu219) of Human CLEC4E fused with a polyhistidine tag at the Cterminus.
Description: CType Lectin Domain Family 4 Member E (CLEC4E) is a 219 amino acid singlepass type II membrane protein that contains one Ctype Lectin domain. It is expressed in monocytes, CLEC4E functions as a downstream target of C/EBP beta and is thought to play a role in the inflammatory response, possibly via transcriptional control of C/EBP beta. CLEC4E may play a role in the response to inflammatory stimuli in peritoneal macrophages and may be involved in immune surveillance processes under transcriptional control of CEBPB. Human CLEC4E shares 67% sequence identity with its mouse counterpart, suggesting a similar function between species. CLEC4E exists as multiple alternatively spliced isoforms that are encoded by a gene which maps to a natural killer gene complex region on human chromosome 12.
Source: HEK293 Cells
Species: Human
Tag: His
Form: Lyophilized from a 0.2 μM filtered solution of 20mM PB, 150mM NaCl, pH 7.4
AA Sequence: RCVVTFRIFQ TCDEKKFQLP ENFTELSCYN YGSGSVKNCC PLNWEYFQSS CYFFSTDTIS WALSLKNCS AMGAHLVVIN SQEEQEFLSY KKPKMREFFI GLSDQVVEGQ WQWVDGTPLT K SLSFWDVG EPNNIATLED CATMRDSSNP RQNWNDVTCF LNYFRICEMV GINPLNKGKS LV DHHHHHH *
Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Notes: For research use only.
Storage: Lyophilized protein should be stored at less than 20°C. though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C. for 2-7 days.Aliquots of reconstituted samples are stable at less than 20°C. for 3 months.
Gene Name: CLEC4E C-type lectin domain family 4, member E [ Homo sapiens ]
Official Symbol: CLEC4E
Synonyms: CLEC4E; C-type lectin domain family 4, member E; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9 , CLECSF9; C-type lectin domain family 4 member E; mincle; C-type lectin superfamily member 9; macrophage-inducible C-type lectin; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9; MINCLE; CLECSF9;
Gene ID: 26253
mRNA Refseq: NM_014358
Protein Refseq: NP_055173
MIM: 609962
UniProt ID: Q9ULY5
Chromosome Location: 12p13.31
Pathway: Tuberculosis, organism-specific biosystem; Tuberculosis, conserved biosystem;
Function: binding; receptor activity; sugar binding;

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