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Native Human PGC

Cat.No.: PGC-8318H
Product Overview: Pepsinogen II (Pepsinogen C) was purified from Human Gastric Mucosa.
Description: This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
Source: Human
Species: Human
Form: Not lyophilised.
Purity: Purified.
Gene Name: PGC progastricsin (pepsinogen C) [ Homo sapiens ]
Official Symbol: PGC
Synonyms: PGC; progastricsin (pepsinogen C); gastricsin; pepsin C; pepsinogen C; preprogastricsin; pepsinogen group II; PEPC; PGII; FLJ99563;
Gene ID: 5225
mRNA Refseq: NM_001166424
Protein Refseq: NP_001159896
MIM: 169740
UniProt ID: P20142
Chromosome Location: 6p21.1
Function: aspartic-type endopeptidase activity; peptidase activity;

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