"NRG2" Related Products

Recombinant Human NRG2

Cat.No.: NRG2-266H
Product Overview: Recombinant Human NRG2, encoding Human NRG2 full-length ORF (AAI66615.1), was expressed in Wheat germ.
Description: This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described.
Source: Wheat germ
Species: Human
Form: Liquid
Molecular Mass: 93.8 kDa
AA Sequence: MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEER RRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPPRAKQDSAPL
Storage: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.
Gene Name: NRG2 neuregulin 2 [ Homo sapiens ]
Official Symbol: NRG2
Synonyms: NRG2; neuregulin 2; pro-neuregulin-2, membrane-bound isoform; divergent of neuregulin 1; Don 1; HRG2; neural and thymus derived activator for ErbB kinases; NTAK; pro-NRG2; divergent of neuregulin-1; neural- and thymus-derived activator for ErbB kinases; DON1;
Gene ID: 9542
mRNA Refseq: NM_001184935
Protein Refseq: NP_001171864
MIM: 603818
UniProt ID: O14511
Chromosome Location: 5q23-q33
Pathway: Downregulation of ERRB2:ERBB3 signaling, organism-specific biosystem; ErbB receptor signaling network, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, conserved biosystem; ErbB2/ErbB3 signaling events, organism-specific biosystem; GRB2 events in ERBB2 signaling, organism-specific biosystem;
Function: ErbB-3 class receptor binding; epidermal growth factor receptor binding; epidermal growth factor-activated receptor activity; growth factor activity; receptor binding;

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