"CHRDL1" Related Products

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Recombinant Human Chordin-Like 1, His-tagged

Cat. No.: CHRDL1-3189H
Product Overview: Recombinant Human CHRDL1 (Glu22-Cys450) fused with a C­terminal and 10­His tag, was expressed in Mouse NSO Cells.
Description: This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described.
Source: Mouse NSO Cells
Molecular Mass: The protein has a calculated molecular mass of 50 kDa. The apparent molecular mass of the recombinant protein is approximately 60 KDa in SDS-PAGE under reducing conditions.
Predicted N terminal: Glu22
Formulation: Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA.
Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Activity: Measured by its ability to inhibit BMP-4-induced activity in MC3T3‑E1 mouse preosteoblast cells. The ED50 for this effect is typically 0.7 - 3.5 µg/mL in the presence of 50 ng/mL rhBMP-4 and 1 µg/mL of rmTSG.
Reconstitution: Reconstitute at 200 µg/mL in sterile 4 mM HCl.
EndotoxinLevel: < 0.01 EU per 1 μg of the protein by the LAL method.
Storage: 12 months from date of receipt, ­20 to ­70 °C as supplied. Avoid repeated freeze­thaw cycles.
OfficialSymbol: CHRDL1
Gene Name: CHRDL1 chordin-like 1 [ Homo sapiens ]
Synonyms: chordin-like 1; CHL; VOPT; NRLN1; dA141H5.1; CHRDL1; chordin-like protein 1; neuralin 1; neuralin-1; ventroptin; neurogenesin-1; OTTHUMP00000023853; OTTHUMP00000023854; OTTHUMP00000216338; Neurogenesin-1; Ventroptin; Neuralin-1
Gene ID: 91851
mRNA Refseq: NM_145234
Protein Refseq: NP_660277
MIM: 300350
UniProt ID: Q9BU40
Chromosome Location: Xq23
Pathway: Signaling by BMP; Signal Transduction
Function: BMP signaling pathway; cell differentiation; multicellular organismal development; nervous system development; ossification

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