Cat. No.:	IL8-38H
Product Overview:	Recombinant Human Interleukin-8 produced inE.Coliis single, a non-glycosylated, Polypeptide chain containing 77 amino acids fragment (23-99) and having a total molecular mass of 15kDa with an amino-terminal his-tagged. The IL-8 His is purified by proprietary chromatographic techniques.
Description:	Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor.
Source:	Escherichia Coli.
Physical Appearance:	Sterile Filtered clear solution.
Purity:	Greater than 95.0% as determined by:(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation:	IL8 His (0.17mg/ml) is supplied in 1x PBS and 50% glycerol.
Biological Activity:	Specific Activity of IL8 in chemotaxis of donor PBL neutrophils, threshold concentration corresponding to 25ng/ml.
Storage:	Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.

Gene Name:	IL8 interleukin 8 [ Homo sapiens ]
Synonyms:	NAF; GCP1; LECT; LUCT; NAP1; CXCL8; GCP-1; LYNAP; MDNCF; MONAP; NAP-1; IL8; interleukin 8; emoctakin; T cell chemotactic factor neutrophil-activating peptide 1; chemokine (C-X-C motif) ligand 8; beta-thromboglobulin-like protein; granulocyte chemotactic protein 1; monocyte-derived neutrophil chemotactic factor; small inducible cytokine subfamily B, member 8; lymphocyte-derived neutrophil-activating factor; C-X-C motif chemokine 8; Monocyte-derived neutrophil chemotactic factor; IL8/NAP1 form VI; GCP/IL-8 protein III; Neutrophil-activating factor; MDNCF-c; IL8/NAP1 form III; GCP/IL-8 protein I; (Ser-IL-8)72; MDNCF-b; IL8/NAP1 form II; GCP/IL-8 protein IIv(Ala-IL-8)77; Interleukin-8; IL-8; Monocyte-derived neutrophil chemotactic factor; T-cell chemotactic factor Neutrophil-activating protein 1; Protein 3-10C; Monocyte-derived neutrophil-activating peptide; Emoctakin
Gene ID:	3576
mRNA Refseq:	NM_000584
Protein Refseq:	NP_000575
MIM:	146930
UniProt ID:	P10145
Chromosome Location:	4q13-q21
Pathway:	Bladder cancer; Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Epithelial cell signaling in Helicobacter pylori infection; Pathways in cancer; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway
Function:	chemokine activity; interleukin-8 receptor binding; protein binding

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