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Recombinant Human GAD2 Protein, His-tagged

Cat.No. : GAD2-9169H
Product Overview : Recombinant human GAD2 protein with a His-tag was expressed in E. coli
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Description : This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : The protein has a calculated MW of 67.5 kDa.
AA Sequence : MGSSHHHHHHSSGLVPRGSHMASPG SGFWSFGSEDGSGDSENPGTARAWC QVAQKFTGGIGNKLCALLYGDAEKP AESGGSQPPRAAARKAACACDQKPC SCSKVDVNYAFLHATDLLPACDGER PTLAFLQDVMNILLQYVVKSFDRST KVIDFHYPNELLQEYNWELADQPQN LEEILMHCQTTLKYAIKTGHPRYFN QLSTGLDMVGLAADWLTSTANTNMF TYEIAPVFVLLEYVTLKKMREIIGW PGGSGDGIFSPGGAISNMYAMMIAR FKMFPEVKEKGMAALPRLIAFTSEH SHFSLKKGAAALGIGTDSVILIKCD ERGKMIPSDLERRILEAKQKGFVPF LVSATAGTTVYGAFDPLLAVADICK KYKIWMHVDAAWGGGLLMSRKHKWK LSGVERANSVTWNPHKMMGVPLQCS ALLVREEGLMQNCNQMHASYLFQQD KHYDLSYDTGDKALQCGRHVDVFKL WLMWRAKGTTGFEAHVDKCLELAEY LYNIIKNREGYEMVFDGKPQHTNVC FWYIPPSLRTLEDNEERMSRLSKVA PVIKARMMEYGTTMVSYQPLGDKVN FFRMVISNPAATHQDIDFLIEEIER LGQDL
Endotoxin : <1 EU/μg
Purity : >90%
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Storage Buffer : Lyophilized from sterile PBS, pH 8.0, 5% trehalose, 5% mannitol.
Gene Name : GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) [ Homo sapiens (human) ]
Official Symbol : GAD2
Synonyms : GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); glutamate decarboxylase 2 (pancreatic islets and brain, 65kD); glutamate decarboxylase 2; GAD65; GAD-65; 65 kDa glutamic acid decarboxylase; Glutamate decarboxylase-2 (pancreas); glutamate decarboxylase 65 kDa isoform; MGC161605; MGC161607;
Gene ID : 2572
mRNA Refseq : NM_000818
Protein Refseq : NP_000809
MIM : 138275
UniProt ID : Q05329

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is there a genetic component related to GAD2 protein and neurological disorders? 07/17/2022

Yes, genetic variations in the GAD2 gene have been associated with an increased risk of developing certain neurological disorders, indicating a genetic component in their etiology.

Can GAD2 protein levels be manipulated pharmacologically? 10/08/2020

Pharmacological agents targeting GAD2 activity are being explored to modulate GABAergic neurotransmission, potentially offering novel treatments for neurological disorders.

Can GAD2 protein be used as a diagnostic marker for neurological disorders? 12/16/2019

Yes, elevated or reduced levels of GAD2 protein can serve as a diagnostic marker for certain neurological disorders, aiding in their identification and management.

How is GAD2 protein linked to neurological disorders? 06/19/2019

GAD2 protein is linked to neurological disorders like epilepsy, Parkinson's disease, and various psychiatric conditions due to its role in regulating GABA levels, which are crucial for proper neuronal function.

Are there any therapeutic interventions targeting GAD2 protein? 04/24/2019

Research is ongoing to develop therapeutic interventions that modulate GAD2 activity, aiming to restore GABAergic balance in the brain and potentially treat related neurological disorders.

Customer Reviews (3)

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04/14/2023

    The GAD2 protein exhibits remarkable performance in Western blotting (WB) experiments.

    12/13/2022

      The versatility and efficacy of GAD2 in these applications make it an invaluable tool for researchers.

      11/11/2019

        Researchers can rely on GAD2 to deliver reliable and accurate results in ELISA experiments, ensuring precise measurement and quantification of target proteins.

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