Recombinant Human TGM2, His-tagged
Cat.No. : | TGM2-9173H |
Product Overview : | Recombinant human TGM2 protein, fused to His-tag, was expressed in E. coli and purified by His-tag affinity chromatography , Superdex-200, RT-HPLC. |
- Specification
- Gene Information
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Description : | Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. 1×PBS |
Molecular Mass : | 77.3KDa |
Protein length : | 1-687 amino acids |
Purity : | >99% as determined by RT-HPLC |
Storage : | Can be stored at 4℃ for short term (1-2 weeks). For long term storage, store at -20℃ or -70℃ |
Concentration : | 0.35mg/ml |
Gene Name : | TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) [ Homo sapiens ] |
Official Symbol : | TGM2 |
Synonyms : | TGM2; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); protein-glutamine gamma-glutamyltransferase 2; TGC; TG(C); TGase C; TGase H; TGase-2; TGase-H; C polypeptide; transglutaminase C; transglutaminase H; transglutaminase-2; tissue transglutaminase; protein-glutamine-gamma-glutamyltransferase; TG2; GNAH; G-ALPHA-h; |
Gene ID : | 7052 |
mRNA Refseq : | NM_004613 |
Protein Refseq : | NP_004604 |
MIM : | 190196 |
UniProt ID : | P21980 |
Chromosome Location : | 20q12 |
Pathway : | Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem; Thromboxane A2 receptor signaling, organism-specific biosystem; |
Function : | GTP binding; metal ion binding; protein binding; protein domain specific binding; protein-glutamine gamma-glutamyltransferase activity; transferase activity, transferring acyl groups; |
Products Types
◆ Recombinant Protein | ||
Tgm2-2130R | Recombinant Rat Tgm2 Protein, His-tagged | +Inquiry |
TGM2-628H | Active Recombinant Human TGM2 Protein, His-tagged | +Inquiry |
TGM2-670H | Recombinant Human TGM2 Protein, MYC/DDK-tagged | +Inquiry |
Tgm2-900M | Recombinant Mouse Tgm2 Protein, His-tagged | +Inquiry |
TGM2-0191H | Recombinant Human TGM2 Protein (M1-A687), His tagged | +Inquiry |
◆ Lysates | ||
TGM2-686HCL | Recombinant Human TGM2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTGM2 levels and activity can serve as diagnostic markers in certain conditions, providing insights into the progression and severity of diseases.
TGM2 has been associated with cardiovascular diseases, contributing to the development of atherosclerosis and vascular calcification.
TGM2 plays a role in fibrosis by promoting the cross-linking of extracellular matrix proteins, contributing to tissue stiffness and impaired organ function.
TGM2 is involved in modulating inflammation and immune responses, influencing processes such as cytokine production and leukocyte adhesion.
Genetic variations in TGM2 have been identified, and certain mutations may influence susceptibility to specific diseases or alter the enzyme's functionality.
Customer Reviews (3)
Write a reviewThe TGM2 protein has demonstrated its efficacy in protein electron microscopy structure analysis.
Whether utilized in protein-protein interaction studies or enzymatic assays, this protein exhibits robust performance, enabling accurate data generation and analysis.
This cutting-edge technique allows for the visualization and characterization of protein structures at the atomic level, providing insights into their function and potential therapeutic targets.
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