"ADIPOQ" Related Products

Expand
Expand

Recombinant Human ADIPOQ, Trimeric Form

Cat. No.: ADIPOQ-47H
Product Overview: Trimeric form of Recombinant Human Adiponectin trimeric form was expressed in HEK293 cells. The cystenine 39 was replaced with Alanine (C39A) 9. hAd-C39A can only form trimer, but not hexamer or HMW form.
Description: Adiponectin is a hormone exclusively expressed from adipose tissue. Many studies demonstrate that Adiponectin has direct anti-diabetic, anti-atherogenic and anti-inflammatory functions. APM-1 can increase insulin sensitivity of skeletal muscle. Attenuate hepatic lipogenesis and gluconeogenesis, regulate NO production in endothelial cells, inhibit proliferation of smooth muscle cells and prevent lipid accumulation of macrophage cells. In the circulation, Adiponectin is present as three different oligomeric complexes, including the high molecular weight (HMW), the middle molecular weight (MMW, also called hexamer) and low molecular weight (MMW, also called trimer) forms 8. Different oligomeric complex of Adiponectin activates different signaling pathways and exerts distinct functions.
Source: HEK293 cells (Human embryonic kidney cell line).
Purity: Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence: ETTTQGPGVL LPLPKGAATG WMAGIPGHPG HNGAPGRDGR DGTPGEKGEK GDPGLIGPKG DIGETGVPGA EGPRGFPGIQ GRKGEPGEGA YVYRSAFSVG LETYVTIPNM PIRFTKIFYN QQNHYDGSTG KFHCNIPGLY YFAYHIVYMK DVKVSLFKKD KAMLFTYDQY QENNVDQASG SVLLHLEVGD QVWLQVYGEG ERNGLYADND NDSTFTGFLL YHDTNDYKDD DDK.
Formulation: Sterile filtered and lyophilized from 0.5 mg/ml in 0.05M phosphate buffer, 0.05M NaCl, pH 7.2.
Solubility: Add 0.2 ml of deionized water and let the lyophilized pellet dissolve completely.
Storage: Store lyophilized Adiponectin at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. The lyophilized AdipoQ remains stable until the expiry date when stored at -20°C.
Activity: ED50= 3-8.5 μg/mL, as determined by its ability to inhibit proliferation of HASMCs induced by HB EGF.
Applications: In vitro, ex vivo and in vivo activity analysis, binding assay et al.
OfficialSymbol: ADIPOQ
Gene Name: ADIPOQ adiponectin, C1Q and collagen domain containing [ Homo sapiens ]
Synonyms: ADIPOQ; adiponectin, C1Q and collagen domain containing; ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1; adiponectin; gelatin-binding protein 28; adipose specific collagen-like factor; 30 kDa adipocyte complement-related protein; adipocyte complement-related 30 kDa protein; adipose most abundant gene transcript 1 protein
Gene ID: 9370
mRNA Refseq: NM_004797
Protein Refseq: NP_004788
MIM: 605441
UniProt ID: Q15848
Chromosome Location: 3q27
Pathway: Adipocytokine signaling pathway; PPAR signaling pathway; Type II diabetes mellitus
Function: cytokine activity; eukaryotic cell surface binding; hormone activity; protein homodimerization activity

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information


Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.