Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Active Recombinant Human ADIPOQ, Trimeric Form

Cat.No. : ADIPOQ-47H
Product Overview : Trimeric form of Recombinant Human Adiponectin trimeric form was expressed in HEK293 cells. The cystenine 39 was replaced with Alanine (C39A) 9. hAd-C39A can only form trimer, but not hexamer or HMW form.
  • Specification
  • Gene Information
  • Related Products
Cat. No. : ADIPOQ-47H
Description : Adiponectin is a hormone exclusively expressed from adipose tissue. Many studies demonstrate that Adiponectin has direct anti-diabetic, anti-atherogenic and anti-inflammatory functions. APM-1 can increase insulin sensitivity of skeletal muscle. Attenuate hepatic lipogenesis and gluconeogenesis, regulate NO production in endothelial cells, inhibit proliferation of smooth muscle cells and prevent lipid accumulation of macrophage cells. In the circulation, Adiponectin is present as three different oligomeric complexes, including the high molecular weight (HMW), the middle molecular weight (MMW, also called hexamer) and low molecular weight (MMW, also called trimer) forms 8. Different oligomeric complex of Adiponectin activates different signaling pathways and exerts distinct functions.
Source : HEK293 cells (Human embryonic kidney cell line).
Purity : Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence : ETTTQGPGVL LPLPKGAATG WMAGIPGHPG HNGAPGRDGR DGTPGEKGEK GDPGLIGPKG DIGETGVPGA EGPRGFPGIQ GRKGEPGEGA YVYRSAFSVG LETYVTIPNM PIRFTKIFYN QQNHYDGSTG KFHCNIPGLY YFAYHIVYMK DVKVSLFKKD KAMLFTYDQY QENNVDQASG SVLLHLEVGD QVWLQVYGEG ERNGLYADND NDSTFTGFLL YHDTNDYKDD DDK.
Formulation : Sterile filtered and lyophilized from 0.5 mg/ml in 0.05M phosphate buffer, 0.05M NaCl, pH 7.2.
Solubility : Add 0.2 ml of deionized water and let the lyophilized pellet dissolve completely.
Storage : Store lyophilized Adiponectin at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. The lyophilized AdipoQ remains stable until the expiry date when stored at -20°C.
Activity : ED50= 3-8.5 μg/mL, as determined by its ability to inhibit proliferation of HASMCs induced by HB EGF.
Applications : In vitro, ex vivo and in vivo activity analysis, binding assay et al.
OfficialSymbol : ADIPOQ
Gene Name : ADIPOQ adiponectin, C1Q and collagen domain containing [ Homo sapiens ]
Synonyms : ADIPOQ; adiponectin, C1Q and collagen domain containing; ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1; adiponectin; gelatin-binding protein 28; adipose specific collagen-like factor; 30 kDa adipocyte complement-related protein; adipocyte complement-related 30 kDa protein; adipose most abundant gene transcript 1 protein
Gene ID : 9370
mRNA Refseq : NM_004797
Protein Refseq : NP_004788
MIM : 605441
UniProt ID : Q15848
Chromosome Location : 3q27
Pathway : Adipocytokine signaling pathway; PPAR signaling pathway; Type II diabetes mellitus
Function : cytokine activity; eukaryotic cell surface binding; hormone activity; protein homodimerization activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (12)

Ask a question
Can ADIPOQ proteins be used in cancer treatment? 06/24/2022

There is limited research on the use of ADIPOQ proteins in cancer treatment. However, some studies have suggested that ADIPOQ proteins may have a protective effect against certain types of cancers, including breast, colon, and prostate cancer.

Can ADIPOQ proteins be used in fertility treatments? 03/04/2022

Various conditions and diseases can affect ADIPOQ protein levels, including type 2 diabetes, obesity, metabolic syndrome, polycystic ovary syndrome, and certain cancers.

Can ADIPOQ levels be modulated through lifestyle changes? 01/14/2022

Yes, ADIPOQ levels can be modulated through lifestyle changes. Regular exercise and weight loss can increase ADIPOQ levels in the blood, while a diet high in saturated fats and sugar can decrease ADIPOQ levels.

Can ADIPOQ proteins have an impact on cardiovascular health? 07/14/2021

Yes, ADIPOQ proteins have been shown to have a protective effect on cardiovascular health. High levels of ADIPOQ proteins are associated with lower risk of cardiovascular disease, while low levels of ADIPOQ proteins are associated with increased risk.

How can lifestyle changes affect ADIPOQ protein levels? 02/05/2021

Lifestyle changes such as diet and exercise can significantly affect ADIPOQ protein levels. Eating a healthy diet and maintaining a healthy weight can increase circulating levels of ADIPOQ proteins, while sedentary lifestyle and obesity can decrease ADIPOQ protein levels.

How are ADIPOQ proteins related to obesity? 08/25/2019

Low levels of ADIPOQ proteins in the circulation have been associated with obesity and an increased risk of metabolic disorders such as insulin resistance and type 2 diabetes. High levels of ADIPOQ proteins, on the other hand, have been associated with better insulin sensitivity and a lower risk of metabolic disorders.

Are there any medications that can affect ADIPOQ levels? 07/30/2019

Some medications, such as thiazolidinediones (TZDs), commonly used to treat type 2 diabetes, can increase ADIPOQ levels and improve insulin sensitivity. However, other medications, such as glucocorticoids, used to treat inflammatory conditions, can reduce ADIPOQ levels and worsen insulin resistance.

How can ADIPOQ proteins be measured? 09/30/2018

ADIPOQ protein levels can be measured in the circulation using a blood test or through adipose tissue biopsies. The blood test is a more commonly used diagnostic tool to evaluate ADIPOQ protein levels due to its non-invasive nature.

What are some conditions and diseases that may affect ADIPOQ protein levels? 04/28/2017

Can ADIPOQ proteins be used as a biomarker for metabolic disorders? 09/27/2016

Yes, measuring circulating levels of ADIPOQ proteins can be used as a biomarker for metabolic disorders such as insulin resistance and type 2 diabetes. Low levels of ADIPOQ proteins are associated with an increased risk of these disorders.

Are there any medications that target ADIPOQ proteins? 08/03/2016

Currently, there are no medications that target ADIPOQ proteins directly. However, drugs that improve insulin sensitivity and metabolic function, such as thiazolidinediones (TZDs) and metformin, have been shown to increase circulating levels of ADIPOQ proteins.

What are some potential future applications of ADIPOQ proteins in medicine? 04/26/2016

As research continues to explore the role of ADIPOQ proteins in various physiological processes, they may have potential future applications for the prevention and treatment of metabolic disorders, cardiovascular disease, infertility, and certain types of cancer. Additionally, ADIPOQ proteins may serve as a biomarker for disease and treatment response.

Customer Reviews (5)

Write a review
Reviews
04/15/2019

    the quality of the ADIPOQ protein used in experiments is of utmost importance and can significantly impact the accuracy and reliability of the results obtained.

    05/12/2018

      The packaging and shipping of the protein were both efficient and effective, ensuring that the product arrived in good condition and ready to use.

      03/05/2018

        The protein's stability and shelf-life have exceeded my expectations, allowing me to use it for multiple experiments without worrying about degradation or loss of potency.

        09/04/2017

          In this regard, using a protein of very high quality that meets your experimental needs is essential.

          08/01/2016

            It will ensure that your results are both valid and reproducible, providing you with valuable insights into the expression and function of ADIPOQ.

            Ask a Question for All ADIPOQ Products

            Required fields are marked with *

            My Review for All ADIPOQ Products

            Required fields are marked with *

            0

            Inquiry Basket

            cartIcon
            logo

            FOLLOW US

            Terms and Conditions        Privacy Policy

            Copyright © 2024 Creative BioMart. All Rights Reserved.

            Contact Us

            • /

            Stay Updated on the Latest Bioscience Trends