Recombinant Human PTGR2, His-tagged

• Cat.No.: PTGR2-15845H
• Product Overview: Recombinant human PTGR2 protein, fused to His tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Description: PTGR2 belongs to the medium-chain dehydrogenase/reductase superfamily. PTGR2 catalyzes an NADPH-dependent reduction of the conjugated alpha,beta-unsaturated double bond of 15-keto-PGE(2), a key step in terminal inactivation of prostaglandins and suppression of PPARgamma-mediated adipocyte differentiation. Selective inhibition of PTGR2 may contribute to the improvement of insulin sensitivity with fewer side effects.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 41.1 kDa (375aa), confirmed by MALDI-TOF
• Protein length: 1-351aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMIVQRV VLNSRPGKNG NPVAENFRME EVYLPDNINE GQVQVRTLYL SVDPYMRCRM NEDTGTDYIT PWQLSQVVDG GGIGIIEESK HTNLTKGDFV TSFYWPWQTK VILDGNSLEK VDPQLVDGHL SYFLGAIGMP GLTSLIGIQE KGHITAGSNKTMVVSGAAGA CGSVAGQIGH FLGCSRVVGI CGTHEKCILL TSELGFDAAI NYKKDNVAEQ LRESCPAGVD VYFDNVGGNI SDTVISQMNE NSHIILCGQI SQYNKDVPYP PPLSPAIEAI QKERNITRER FLVLNYKDKF EPGILQLSQW FKEGKLKIKE TVINGLENMG AAFQSMMTGGNIGKQIVCIS EEISL
• Purity: >90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term. For long term storage, aliquot and store at at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: PTGR2 prostaglandin reductase 2 [ Homo sapiens ]
• Official Symbol: PTGR2
• Synonyms: PTGR2; prostaglandin reductase 2; ZADH1, zinc binding alcohol dehydrogenase domain containing 1; FLJ39091; PRG-2; 15-oxoprostaglandin 13-reductase; 15-oxoprostaglandin-delta13-reductase; zinc binding alcohol dehydrogenase, domain containing 1; zinc-binding alcohol dehydrogenase domain-containing protein 1; PGR2; ZADH1; FLJ99229; DKFZp686P10120
• Gene ID: 145482
• mRNA Refseq: NM_152444
• Protein Refseq: NP_689657
• MIM: 608642
• UniProt ID: Q8N8N7
• Chromosome Location: 14q24.1-q24.2
• Function: 15-oxoprostaglandin 13-oxidase activity; nucleotide binding; oxidoreductase activity; NOT zinc ion binding