Active Recombinant Human CD59, His-tagged
Cat.No. : | CD59-1600H |
Product Overview : | Recombinant Human CD59 (Leu26-Asn102) fused with a Cterminal 10His tag, was expressed in Mouse NSO Cells. |
- Specification
- Gene Information
- Related Products
Cat. No. : | CD59-1600H |
Description : | This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. |
Source : | Mammalian cells |
Molecular Mass : | 10.3 kDa |
Predicted N terminal : | Leu26 |
Formulation : | Lyophilized from a 0.2 μm filtered solution in PBS. |
Purity : | >95%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Activity : | Measured by its binding ability in a functional ELISA. When recombinant human C9 is coated at 5 µg/mL (100 µL/well), the concentration of Recombinant Human CD59 that produces 50% optimal binding response is typically 0.6‑3 µg/mL. |
EndotoxinLevel : | < 0.01 EU per 1 μg of the protein by the LAL method. |
Reconstitution : | Reconstitute at 100 µg/mL in PBS. |
Storage : | 12 months from date of receipt, 20 to 70 °C as supplied. Avoid repeated freezethaw cycles. |
OfficialSymbol : | CD59 |
Gene Name : | CD59 CD59 molecule, complement regulatory protein [ Homo sapiens ] |
Synonyms : | CD59; CD59 molecule, complement regulatory protein; CD59 antigen p18 20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) , CD59 antigen, complement regulatory protein , MIC11, MIN1, MIN2, MIN3, MSK21; CD59 glycoprotein; 16.3A5; EJ16; EJ30; EL32; G344; p18 20; protectin; 1F5 antigen; MEM43 antigen; Ly-6-like protein; T cell-activating protein; human leukocyte antigen MIC11; lymphocytic antigen CD59/MEM43; 20 kDa homologous restriction factor; membrane inhibitor of reactive lysis; membrane attack complex inhibition factor; membrane attack complex (MAC) inhibition factor; surface anitgen recognized by monoclonal 16.3A5; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344); 1F5; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; HRF-20; MAC-IP; p18-20; MGC2354; FLJ38134; FLJ92039 |
Gene ID : | 966 |
mRNA Refseq : | NM_000611 |
Protein Refseq : | NP_000602 |
MIM : | 107271 |
UniProt ID : | P13987 |
Chromosome Location : | 11p13 |
Pathway : | Arf6 trafficking events; Complement and coagulation cascades; Hematopoietic cell lineage |
Function : | protein binding; complement binding |
Products Types
◆ Recombinant Protein | ||
CD59-692H | Recombinant Human CD59 Protein, His and C-hFc-tagged | +Inquiry |
CD59-140C | Recombinant Cynomolgus Monkey CD59 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD59-0836H | Recombinant Human CD59 Protein, GST-Tagged | +Inquiry |
CD59-543H | Recombinant Human CD59 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD59-918R | Recombinant Rat CD59 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CD59-1968HCL | Recombinant Human CD59 cell lysate | +Inquiry |
CD59-1019CCL | Recombinant Cynomolgus CD59 cell lysate | +Inquiry |
CD59-1365RCL | Recombinant Rat CD59 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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