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Recombinant Human ACAN, His-tagged

Cat. No.: ACAN-102H
Product Overview: Recombinant Human ACAN (NP_037359, Val20-Gly675) fused with a C-terminal 10-His tag, was expressed in Mouse NSO Cells
Description: This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.
Source: Mouse NSO Cells
Molecular Mass: The recombinant human protein predicts a molecular mass of 74 kDa. The apparent molecular mass of the protein is approximately 120 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation: Lyophilized from a 0.2 µm filtered solution in MES and NaCl.
Predicted N terminal: Val20
Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Bio-activity: Measured by its binding ability in a functional ELISA.
Endotoxin Level: < 1.0 EU per 1 μg of the protein by the LAL method.
Storage: Store it under sterile conditions at -20oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
OfficialSymbol: ACAN
Gene Name: ACAN aggrecan [ Homo sapiens ]
Synonyms: ACAN; aggrecan; AGC1; SEDK; AGCAN; CSPG1; MSK16; CSPGCP; aggrecan core protein; large aggregating proteoglycan; cartilage-specific proteoglycan core protein; chondroitin sulfate proteoglycan core protein 1; aggrecan 1; aggrecan proteoglyca; Aggrecan core protein 2
Gene ID: 176
mRNA Refseq: NM_013227
Protein Refseq: NP_037359
MIM: 155760
UniProt ID: P16112
Chromosome Location: 15q26.1
Function: extracellular matrix structural constituent; hyaluronic acid binding; protein binding; sugar binding

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