"ACLY" Related Products


Recombinant Human ACLY, GST-tagged

Cat.No.: ACLY-9291H
Product Overview: Recombinant Human ACLY protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.
Source: E.coli
Species: Human
Tag: GST
Protein length: 751-1101a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: ACLY ATP citrate lyase [ Homo sapiens ]
Official Symbol: ACLY
Synonyms: ACLY; ATP citrate lyase; ATP-citrate synthase; ACL; ATP citrate synthase; ATPCL; CLATP; citrate cleavage enzyme; ATP-citrate (pro-S-)-lyase;
Gene ID: 47
mRNA Refseq: NM_001096
Protein Refseq: NP_001087
MIM: 108728
UniProt ID: P53396
Chromosome Location: 17q21.2
Pathway: ChREBP activates metabolic gene expression, organism-specific biosystem; Citrate cycle (TCA cycle), organism-specific biosystem; Citrate cycle (TCA cycle), conserved biosystem; Fatty Acid Biosynthesis, organism-specific biosystem; Fatty Acyl-CoA Biosynthesis, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem;
Function: ATP binding; ATP citrate synthase activity; binding; ligase activity; metal ion binding; nucleotide binding; succinate-CoA ligase (ADP-forming) activity; transferase activity;

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