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Recombinant Human AFP, His-tagged

Cat.No.: AFP-9461H
Product Overview: Recombinant Human AFP protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description: This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
Source: E.coli
Species: Human
Tag: His
Protein length: 260-609a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name: AFP alpha-fetoprotein [ Homo sapiens ]
Official Symbol: AFP
Synonyms: AFP; alpha-fetoprotein; HPAFP; FETA; alpha-fetoglobulin; alpha-1-fetoprotein;
Gene ID: 174
mRNA Refseq: NM_001134
Protein Refseq: NP_001125
UniProt ID: P02771
Chromosome Location: 4q11-q13
Pathway: Direct p53 effectors, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem;
Function: metal ion binding;

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