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Recombinant Human AGTRAP, GST-tagged

Cat.No. : AGTRAP-9486H
Product Overview : Recombinant Human AGTRAP protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-152a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : AGTRAP angiotensin II receptor-associated protein [ Homo sapiens ]
Official Symbol : AGTRAP
Synonyms : AGTRAP; angiotensin II receptor-associated protein; type-1 angiotensin II receptor-associated protein; ATRAP; AT1 receptor-associated protein; ATI receptor-associated protein; angiotensin II, type I receptor-associated protein; MGC29646;
Gene ID : 57085
mRNA Refseq : NM_001040194
Protein Refseq : NP_001035284
MIM : 608729
UniProt ID : Q6RW13
Chromosome Location : 1p36.22
Function : angiotensin type II receptor activity; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Is AGTRAP involved in the pathophysiology of cardiovascular diseases? 11/30/2021

Yes, dysregulation of AGTRAP expression or function has been implicated in various cardiovascular conditions, including hypertension, cardiac hypertrophy, and heart failure.

Can AGTRAP affect AGTR1 expression levels? 10/23/2021

Yes, AGTRAP can regulate AGTR1 expression by influencing its trafficking and degradation, thus impacting the overall abundance of AGTR1 receptors.

How does AGTRAP influence AGTR1-mediated intracellular signaling? 06/12/2021

AGTRAP can modulate AGTR1 signaling by affecting the receptor's coupling to downstream signaling pathways, including G proteins and β-arrestins.

Where is AGTRAP primarily expressed in the human body? 02/13/2021

AGTRAP is widely expressed in various tissues, including the heart, kidney, liver, and brain.

What is the role of AGTRAP in blood pressure regulation? 01/27/2021

AGTRAP acts as a negative regulator of AGTR1, thereby modulating the effects of angiotensin II on blood pressure control and vascular function.

What is the subcellular localization of AGTRAP? 09/10/2020

AGTRAP is primarily localized in the endoplasmic reticulum (ER) and Golgi apparatus, where it interacts with AGTR1 during receptor maturation and trafficking.

How does AGTRAP interact with AGTR1? 06/11/2020

AGTRAP physically associates with AGTR1 and modulates its activity by influencing receptor trafficking, signaling, and desensitization.

Are there any AGTRAP-related diseases or disorders? 03/19/2020

While the precise involvement of AGTRAP in specific diseases is still being elucidated, dysregulation of AGTRAP has been associated with cardiovascular diseases, hypertension, and altered response to angiotensin II.

Are there any known AGTRAP-binding partners? 07/20/2019

AGTRAP has been reported to interact with several proteins involved in receptor trafficking, including G protein-coupled receptor-associated sorting proteins (GASP), which influence AGTR1 cell surface expression.

What techniques are commonly used to study AGTRAP function? 05/21/2018

Techniques such as immunoprecipitation, co-immunoprecipitation, fluorescence microscopy, and genetic manipulation in cellular and animal models are employed to investigate AGTRAP's role and molecular mechanisms.

Customer Reviews (5)

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Reviews
01/05/2022

    It was delivered quickly, and the product was of exceptional quality, meeting all my research needs.

    12/19/2021

      Outstanding products. Impressive results!

      08/27/2020

        The protein I purchased was a game-changer for my experiments. Its high activity and purity significantly improved the reliability of my findings

        04/10/2019

          Reliable and high-quality protein. Recommended!

          07/03/2018

            I've been using proteins for years, and this one ranks among the best.

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