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Recombinant Human AKAP14, GST-tagged

Cat.No. : AKAP14-9520H
Product Overview : Recombinant Human AKAP14 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The protein anchors PKA in ciliary axonemes and, in this way, may play a role in regulating ciliary beat frequency. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-197a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : AKAP14 A kinase (PRKA) anchor protein 14 [ Homo sapiens ]
Official Symbol : AKAP14
Synonyms : AKAP14; A kinase (PRKA) anchor protein 14; A-kinase anchor protein 14; AKAP28; AKAP 28; AKAP-14; A-kinase anchoring protein 28; A-kinase anchor protein 28 kDa; protein kinase A-anchoring protein 14; PRKA14;
Gene ID : 158798
mRNA Refseq : NM_001008534
Protein Refseq : NP_001008534
MIM : 300462
UniProt ID : Q86UN6
Chromosome Location : Xq24

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (20)

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Can AKAP14 be used as a biomarker for any diseases? 01/01/2023

The utility of AKAP14 as a biomarker for specific diseases is not well established. While alterations in AKAP14 expression have been observed in certain cancers and other diseases, more research is required to determine its diagnostic or prognostic value. Additionally, its potential as a biomarker may vary depending on the specific disease and its stage.

Does AKAP14 have any specific binding partners? 12/02/2022

AKAP14 interacts with various proteins, including PKA, DNA repair factors, chromatin modifiers, and transcription factors. It binds to the regulatory subunits of PKA, directing the kinase to specific subcellular locations. Additionally, AKAP14 has been found to interact with proteins involved in DNA double-strand break repair, such as ATM and BRCA1.

Is AKAP14 involved in any other cellular processes? 08/02/2022

In addition to its role in DNA repair and cellular signaling, AKAP14 has been implicated in other cellular processes. It has been shown to be involved in cell cycle regulation, where it interacts with cyclins and cyclin-dependent kinases. AKAP14 has also been linked to nuclear organization and chromatin remodeling, suggesting a potential role in gene expression regulation and epigenetic modifications.

Is AKAP14 associated with any diseases? 07/10/2022

There is limited research on the involvement of AKAP14 in disease processes. However, alterations in AKAP14 expression or function have been reported in certain cancers, such as hepatocellular carcinoma and colorectal cancer. Further studies are needed to elucidate the precise role of AKAP14 in these diseases and determine its potential as a therapeutic target or diagnostic/prognostic biomarker.

What are the current research areas focused on AKAP14? 07/01/2022

Current research on AKAP14 is focused on elucidating its molecular mechanisms and understanding its roles in various cellular processes. This includes investigating its interactions with different proteins and its impact on signaling pathways, DNA repair mechanisms, and gene expression regulation. Additionally, studies are exploring the potential therapeutic applications of AKAP14 as a target for drug development.

Does AKAP14 have any roles in DNA repair? 06/20/2022

AKAP14 has been implicated in the DNA damage response and DNA repair processes. Studies have shown that AKAP14 interacts with DNA damage response proteins, such as ATM and ATR, and is recruited to sites of DNA damage. It has also been found to participate in the repair of DNA double-strand breaks. However, the exact mechanisms by which AKAP14 contributes to DNA repair and its specific roles in different repair pathways require further investigation.

How is AKAP14 involved in cellular signaling? 09/06/2021

AKAP14 acts as a scaffold protein in cellular signaling pathways, bringing together multiple signaling components and enzymes to regulate their activity and localization. By anchoring proteins such as PKA and transcription factors, AKAP14 helps to coordinate their signaling activities and ensure proper signal transduction within cells.

Does AKAP14 have any post-translational modifications? 07/22/2021

Post-translational modifications of AKAP14 have been reported, although the specific modifications are not well characterized. It has been suggested that AKAP14 may undergo phosphorylation, acetylation, or ubiquitination, which can impact its stability, localization, and interactions with other proteins. Further research is needed to fully understand the extent and functional significance of these modifications on AKAP14.

What are the functional domains of AKAP14? 08/11/2020

AKAP14 contains several functional domains that contribute to its cellular functions. These include a nuclear localization signal (NLS) that facilitates its entry into the nucleus, a coiled-coil domain that mediates protein-protein interactions, and a C-terminal domain that is important for AKAP14's association with chromatin. Additionally, AKAP14 has a putative DNA-binding domain and multiple phosphorylation sites that may regulate its activity and interactions with other proteins.

Can AKAP14 be used in gene therapy or genetic engineering applications? 07/04/2020

The use of AKAP14 in gene therapy or genetic engineering applications has not been extensively explored. However, given its involvement in DNA repair mechanisms and potential roles in gene expression regulation, AKAP14 may have implications in these fields. Further research is required to determine the feasibility and effectiveness of using AKAP14 in gene therapy or genetic engineering approaches.

Can AKAP14 be targeted for therapeutic purposes? 12/22/2019

As of now, there are no specific therapeutic interventions targeting AKAP14. However, its involvement in cellular signaling and DNA repair processes suggests that modulating its activity or interactions could have potential therapeutic benefits. Further research is required to understand the molecular mechanisms of AKAP14 and explore its potential as a target for drug development.

Are there any drugs or compounds that target AKAP14? 08/31/2019

Currently, there are no specific drugs or compounds that are designed to target AKAP14. However, certain drugs that modulate cellular signaling pathways or DNA repair mechanisms may indirectly affect AKAP14 function. For example, inhibitors of protein kinases or DNA repair enzymes may impact AKAP14-mediated signaling or DNA repair processes. Further research is needed to identify and develop specific AKAP14-targeting agents.

What are the potential therapeutic implications of targeting AKAP14? 05/02/2019

Targeting AKAP14 could have potential therapeutic implications in various diseases. For example, modulating AKAP14's interactions with signaling proteins or DNA repair factors could impact cellular signaling pathways or DNA repair mechanisms, making it a potential target for cancer therapies. Additionally, understanding AKAP14's roles in other cellular processes may reveal novel therapeutic targets for a range of diseases. However, further research is necessary to fully explore the therapeutic potential of targeting AKAP14.

Is AKAP14 involved in cell signaling pathways? 05/02/2019

AKAP14 has been shown to interact with proteins involved in various cellular signaling pathways. For example, it interacts with protein kinase A (PKA) and protein kinase C (PKC), suggesting a potential role in modulating their activities and downstream signaling events. Additionally, AKAP14 has been found to interact with components of the Wnt signaling pathway. However, the precise contributions of these interactions and their impact on cell signaling require further exploration.

Can AKAP14 interact with proteins other than PKA? 07/08/2018

Yes, AKAP14 can interact with a diverse range of proteins beyond PKA. It can interact with DNA repair factors, chromatin modifiers, transcription factors, and other signaling proteins. These interactions allow AKAP14 to coordinate and regulate various cellular processes and signaling pathways in addition to PKA-mediated signaling.

Where is AKAP14 located within cells? 07/21/2017

AKAP14 is primarily localized in the nucleus, where it interacts with chromatin and nucleolar components. It contains nuclear localization signals that facilitate its entry into the nucleus. However, AKAP14 has also been observed in the cytoplasm, suggesting its involvement in cytoplasmic signaling pathways as well.

Does AKAP14 have any physiological or pathological functions in specific organs or tissues? 02/21/2017

The physiological and pathological functions of AKAP14 in specific organs or tissues are not well understood. While AKAP14 is expressed in various tissues, its roles in different organs are not fully characterized. Studies suggest that AKAP14 may play a part in the development and maintenance of certain tissues, such as the testes and heart, but further research is needed to determine its tissue-specific functions.

Are there any genetic mutations or polymorphisms associated with AKAP14? 02/10/2017

There have been limited studies examining genetic variations in AKAP14 and their association with diseases or phenotypic traits. However, a few studies have identified single nucleotide polymorphisms (SNPs) in AKAP14 that may be linked to certain clinical conditions, such as schizophrenia and essential hypertension. Further research is needed to validate these associations and understand the functional impact of these genetic variations.

Are there any animal models lacking or overexpressing AKAP14? 07/07/2016

As of now, there are no reported animal models specifically lacking or overexpressing AKAP14. Generating such animal models could provide valuable insights into the physiological and pathological roles of AKAP14. Animal models lacking or overexpressing AKAP14 could help elucidate its functions in various cellular processes and their impact on development, disease progression, and response to therapies.

Are there any disease associations or mutations identified in AKAP14? 06/15/2015

To date, there have been no specific disease associations or mutations identified in AKAP14. However, dysregulation or alterations in AKAP14 expression or activity may have implications in various diseases, including cancer and neurological disorders. Studying AKAP14 in disease contexts may uncover its potential as a diagnostic marker or therapeutic target.

Customer Reviews (4)

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Reviews
03/15/2023

    The extraordinary quality of the AKAP14 protein combined with the manufacturer's superb technical assistance instills a sense of confidence in the success of my experiments.

    05/11/2022

      The manufacturer's commitment to exceptional customer support greatly enhances my research experience and guarantees seamless progress in my work.

      11/23/2021

        In addition to its outstanding quality, the manufacturer provides excellent technical support that has proven to be immensely beneficial.

        03/22/2020

          I am truly appreciative of this remarkable product, as it undoubtedly contributes to the advancement of my scientific pursuits.

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