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Recombinant Human ALDH8A1, His-tagged

Cat.No. : ALDH8A1-9565H
Product Overview : Recombinant Human ALDH8A1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
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Description : This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene.
Source : E.coli
Species : Human
Tag : His
Protein length : C-term-352a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : ALDH8A1 aldehyde dehydrogenase 8 family, member A1 [ Homo sapiens ]
Official Symbol : ALDH8A1
Synonyms : ALDH8A1; aldehyde dehydrogenase 8 family, member A1; aldehyde dehydrogenase family 8 member A1; ALDH12; aldehyde dehydrogenase 12; aldehyde dehydrogenase family protein; DJ352A20.2; MGC138650; DKFZp779D2315;
Gene ID : 64577
mRNA Refseq : NM_001193480
Protein Refseq : NP_001180409
MIM : 606467
UniProt ID : Q9H2A2
Chromosome Location : 6q24.1-q25.1
Function : oxidoreductase activity; retinal dehydrogenase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Are there any therapies or treatments specifically targeting the ALDH8A1 protein? 10/22/2022

As of now, there are no specific therapies or treatments targeting the ALDH8A1 protein. The focus is primarily on managing and treating the developmental disorders or diseases associated with ALDH8A1 gene mutations, such as Antley-Bixler syndrome, through supportive and symptomatic care.

What are the potential roles of the ALDH8A1 protein in diseases other than Antley-Bixler syndrome? 02/08/2021

While Antley-Bixler syndrome is the most well-known disease associated with ALDH8A1 gene mutations, there is increasing evidence suggesting potential roles for ALDH8A1 in other diseases. For example, it has been implicated in some forms of cancer, including ovarian and gastric cancer. However, further research is necessary to fully understand its involvement in these conditions.

Are there any other known functions or roles of the ALDH8A1 protein? 10/08/2020

While the primary function of the ALDH8A1 protein is the conversion of retinaldehyde to retinoic acid, the full extent of its functions is still being investigated. Some studies suggest its involvement in the detoxification of certain aldehydes, but further research is needed to fully understand its roles.

Where is the ALDH8A1 protein expressed in the body? 08/21/2020

The ALDH8A1 protein is expressed in various tissues and organs of the body. It is found in high levels in the liver, as well as in other tissues such as the brain, kidney, lung, and small intestine.

How is the ALDH8A1 protein regulated? 08/18/2020

The regulation of ALDH8A1 expression and activity is not fully understood. However, it is known that its expression can be influenced by various factors, including hormones, vitamin A levels, and developmental signaling pathways. Further research is needed to elucidate the precise mechanisms of its regulation.

Are there any known interacting partners or proteins that interact with ALDH8A1? 08/16/2020

The specific protein-protein interactions involving ALDH8A1 are not well-characterized. However, as an enzyme involved in retinoic acid metabolism, it likely interacts with other proteins in the retinoid signaling pathway. Some studies suggest that ALDH8A1 may interact with cellular retinoic acid-binding proteins (CRABP) and retinoic acid receptor (RAR) proteins, but more research is needed to confirm and fully understand these interactions.

Are there any inhibitors or activators of the ALDH8A1 protein? 01/03/2018

Some compounds have been identified as possible inhibitors or activators of ALDH8A1 activity. For example, it has been found that disulfiram, a drug used to treat alcoholism, can inhibit ALDH8A1 activity. However, the therapeutic potential of these compounds in relation to ALDH8A1 function is not yet fully understood.

How is the ALDH8A1 protein related to human health? 06/11/2016

Mutations or dysregulation in the ALDH8A1 gene and protein have been associated with certain developmental disorders and diseases. One example is Antley-Bixler syndrome, a rare genetic disorder characterized by craniosynostosis (premature fusion of the skull bones) and other skeletal and genital abnormalities. ALDH8A1 mutations have been found in individuals with this condition.

Customer Reviews (4)

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10/26/2019

    Researchers utilizing the Aldh8a1 Protein can rely on its robust and reproducible performance in a variety of experimental settings.

    12/20/2018

      This protein has proven to be of great utility in protein electron microscopy structure analysis.

      04/09/2017

        broad applicability make it a valuable asset for a wide range of research endeavors.

        04/27/2016

          The Aldh8a1 Protein comes highly recommended for its exceptional performance, particularly in ELISA assays.

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