Recombinant Human ARRB2, GST-tagged ARRB2-9893H

Recombinant Human ARRB2, GST-tagged

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Recombinant Human ARRB2, GST-tagged

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Cat.No. : ARRB2-9893H
Product Overview : Recombinant Human ARRB2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description : Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : E.coli
Species : Human
Tag : GST
Protein length : 162-408a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : ARRB2 arrestin, beta 2 [ Homo sapiens ]
Official Symbol : ARRB2
Synonyms : ARRB2; arrestin, beta 2; ARR2; beta-arrestin-2; arrestin 3; BARR2; DKFZp686L0365; arrestin beta-2; ARB2;
Gene ID : 409
mRNA Refseq : NM_001257328
Protein Refseq : NP_001244257
MIM : 107941
UniProt ID : P32121
Chromosome Location : 17p13
Pathway : ALK1 signaling events, organism-specific biosystem; Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Arf6 signaling events, organism-specific biosystem; Atypical NF-kappaB pathway, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem;
Function : G-protein coupled receptor binding; angiotensin receptor binding; protein binding; receptor binding; ubiquitin protein ligase binding;

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