Recombinant Human ATL1, GST-tagged

• Cat.No.: ATL1-9984H
• Product Overview: Recombinant Human ATL1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: N-term-350a.a.
• Description: The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: ATL1 atlastin GTPase 1 [ Homo sapiens ]
• Official Symbol: ATL1
• Synonyms: ATL1; atlastin GTPase 1; spastic paraplegia 3A (autosomal dominant) , SPG3, SPG3A; atlastin-1; AD FSP; atlastin; FSP1; GBP-3; hGBP3; GTP-binding protein 3; guanylate-binding protein 3; spastic paraplegia 3 protein A; brain-specific GTP-binding protein; guanine nucleotide-binding protein 3; GBP3; SPG3; HSN1D; SPG3A; AD-FSP; atlastin1
• Gene ID: 51062
• mRNA Refseq: NM_001127713
• Protein Refseq: NP_001121185
• MIM: 606439
• UniProt ID: Q8WXF7
• Chromosome Location: 14q21.3
• Function: GTP binding; GTPase activity; hydrolase activity; identical protein binding; nucleotide binding; protein binding