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Recombinant Human ATP2A1, His-tagged

Cat.No.: ATP2A1-10010H
Product Overview: Recombinant Human ATP2A1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in two transcript variants encoding different isoforms.
Source: E.coli
Species: Human
Tag: His
Protein length: 524-598a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name: ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [ Homo sapiens ]
Official Symbol: ATP2A1
Synonyms: ATP2A1; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; ATP2A; sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA1; calcium pump 1; SR Ca(2+)-ATPase 1; endoplasmic reticulum class 1/2 Ca(2+) ATPase; calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform;
Gene ID: 487
mRNA Refseq: NM_004320
Protein Refseq: NP_004311
MIM: 108730
UniProt ID: O14983
Chromosome Location: 16p12.1
Pathway: Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Hemostasis, organism-specific biosystem; Ion channel transport, organism-specific biosystem; Ion transport by P-type ATPases, organism-specific biosystem;
Function: ATP binding; ATP binding; calcium ion binding; calcium ion binding; calcium-transporting ATPase activity; calcium-transporting ATPase activity; hydrolase activity; hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substan

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