Recombinant Human AUH, His-tagged
Cat.No. : | AUH-10072H |
Product Overview : | Recombinant Human AUH protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
Unit | |
Price | |
Qty |
- Specification
- Gene Information
- Related Products
Description : | The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3 UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | 1-310a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | AUH AU RNA binding protein/enoyl-CoA hydratase [ Homo sapiens ] |
Official Symbol : | AUH |
Synonyms : | AUH; AU RNA binding protein/enoyl-CoA hydratase; AU RNA binding protein/enoyl Coenzyme A hydratase , AU RNA binding protein/enoyl Coenzyme A hydratase; methylglutaconyl-CoA hydratase, mitochondrial; 3-methylglutaconyl-CoA hydratase; AU-binding protein/Enoyl-CoA hydratase; AU-specific RNA-binding enoyl-CoA hydratase; AU RNA binding protein/enoyl-Coenzyme A hydratase; AU RNA-binding protein/enoyl-Coenzyme A hydratase; |
Gene ID : | 549 |
mRNA Refseq : | NM_001698 |
Protein Refseq : | NP_001689 |
MIM : | 600529 |
UniProt ID : | Q13825 |
Chromosome Location : | 9q22 |
Pathway : | Branched-chain amino acid catabolism, organism-specific biosystem; Leucine degradation, leucine => acetoacetate + acetyl-CoA, organism-specific biosystem; Leucine degradation, leucine => acetoacetate + acetyl-CoA, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; |
Function : | RNA binding; enoyl-CoA hydratase activity; lyase activity; mRNA 3-UTR binding; methylglutaconyl-CoA hydratase activity; |
Products Types
◆ Recombinant Protein | ||
Auh-682M | Recombinant Mouse Auh Protein, MYC/DDK-tagged | +Inquiry |
AUH-906M | Recombinant Mouse AUH Protein, His (Fc)-Avi-tagged | +Inquiry |
AUH-308R | Recombinant Rhesus Macaque AUH Protein, His (Fc)-Avi-tagged | +Inquiry |
AUH-3040H | Recombinant Human AUH Protein, MYC/DDK-tagged | +Inquiry |
AUH-479R | Recombinant Rhesus monkey AUH Protein, His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket