"BIN1" Related Products

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Recombinant Human BIN1, GST-tagged

Cat.No. : BIN1-10230H
Product Overview : Recombinant Human BIN1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description : This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-439a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : BIN1 bridging integrator 1 [ Homo sapiens ]
Official Symbol : BIN1
Synonyms : BIN1; bridging integrator 1; AMPHL; myc box-dependent-interacting protein 1; AMPH2; amphiphysin II; SH3P9; amphiphysin-like protein; box dependant MYC interacting protein 1; box-dependent myc-interacting protein 1; MGC10367; DKFZp547F068;
Gene ID : 274
mRNA Refseq : NM_004305
Protein Refseq : NP_004296
MIM : 601248
UniProt ID : O00499
Chromosome Location : 2q14
Pathway : Arf6 trafficking events, organism-specific biosystem;
Function : GTPase binding; protein binding; protein heterodimerization activity;

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