Recombinant Human CATSPER1, GST-tagged

• Cat.No.: CATSPER1-10746H
• Product Overview: Recombinant Human CATSPER1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: N-term-302a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CATSPER1 cation channel, sperm associated 1 [ Homo sapiens ]
• Official Symbol: CATSPER1
• Synonyms: CATSPER1; cation channel, sperm associated 1; cation channel sperm-associated protein 1; CATSPER; hCatSper; sperm ion channel; sperm-associated cation channel 1; SPGF7; MGC33335; MGC33368
• Gene ID: 117144
• mRNA Refseq: NM_053054
• Protein Refseq: NP_444282
• MIM: 606389
• UniProt ID: Q8NEC5
• Chromosome Location: 11q12.1
• Function: protein binding; voltage-gated calcium channel activity; voltage-gated ion channel activity