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Recombinant Human Artemin

Cat.No. : ARTN-12H
Product Overview : Recombinant Human Artemin produced inE.Coliis a disulfide-linked homodimer, non-glycosylated, polypeptide chain containing 2x113 amino acids and having a total molecular mass of 24205 Dalton. Artemin is purified by proprietary chromatographic techniques.
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  • Gene Information
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Cat. No. : ARTN-12H
Description : The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenrative disease. Artemin has been shown in culture to support the survival of a number of periferal neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Four alternatively spliced transcripts have been described, two of which encode the same protein.
Source : Escherichia Coli.
Amino acid sequence : The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Gly-Gly-Pro-Gly.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Purity : Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : Artemin was lyophilized after extensive dialysis against 10mM sodium citrate pH-4.5 and 150mM sodium chloride.
Solubility : It is recommended to reconstitute the lyophilized Artemin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Biological Activity : The Biological activity is calculated by it"s ability to promote survival and neurite outgrowth and dorsal root ganglion neurons.
Storage : Lyophilized Artemin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Artemin should be stored at 4°Cbetween 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : ARTN artemin [ Homo sapiens ]
Synonyms : ARTN; Artemin; EVN; NBN; ENOVIN; neurotrophic factor artemin; Neublastin; neurotrophic factor; artemin; neublastin; Enovin; OTTHUMP00000009173; OTTHUMP00000009174
Gene ID : 9048
mRNA Refseq : NM_001136215
Protein Refseq : NP_001129687
MIM : 603886
UniProt ID : Q5T4W7
Chromosome Location : 1p33-p32
Function : growth factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (8)

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What signaling pathways are activated by the ARTN protein? 08/10/2022

The ARTN protein activates various signaling pathways, including the RET receptor tyrosine kinase pathway and the AKT and MAPK/ERK pathways, to mediate its neurotrophic effects.

Can the ARTN protein promote the survival of neurons under conditions of stress or injury? 06/09/2022

Yes, the ARTN protein has neuroprotective effects and can promote the survival of neurons under conditions of stress or injury, such as oxidative stress or neuronal damage.

Can dysregulation of the ARTN protein contribute to neurodegenerative diseases? 07/30/2020

Dysregulation of the ARTN protein has been implicated in neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Further research is needed to understand the underlying mechanisms.

Is the ARTN protein involved in the development of the nervous system? 06/29/2020

Yes, the ARTN protein is involved in the development of the nervous system. It plays a role in guiding growing axons and promoting the survival and differentiation of neurons during development.

Can the ARTN protein be used as a potential therapeutic target for neurological disorders? 03/26/2020

The potential therapeutic use of the ARTN protein is being explored, particularly for neurodegenerative diseases, but further research is needed to evaluate its effectiveness and safety.

Can the ARTN protein regulate immune responses? 03/15/2020

Yes, the ARTN protein has immunomodulatory properties. It can influence immune cell activity and promote anti-inflammatory responses in certain contexts.

Are there any known mutations in the ARTN gene that lead to neurological disorders? 07/15/2018

As of now, no specific mutations in the ARTN gene linked to neurological disorders have been reported. However, ongoing genomic studies might uncover any potential disease associations.

Does the ARTN protein have any role in pain perception? 02/28/2018

Yes, the ARTN protein has been implicated in pain perception. It has been shown to influence the sensitivity of sensory neurons and modulate pain signaling pathways.

Customer Reviews (3)

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Reviews
11/26/2020

    I highly endorse the utilization of the ARTN Protein for researchers seeking a superior protein solution that not only meets their experimental needs but also benefits from the exceptional technical support provided by the manufacturer.

    09/08/2019

      Their team of experts has been extremely helpful in addressing any concerns or queries I encountered during my experiments.

      11/16/2018

        Its exceptional purity and consistency have consistently yielded reliable and reproducible results, ensuring the accuracy and reliability of my research outcomes.

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