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Recombinant Human Artemin

Cat. No. : ARTN-12H
Product Overview : Recombinant Human Artemin produced inE.Coliis a disulfide-linked homodimer, non-glycosylated, polypeptide chain containing 2x113 amino acids and having a total molecular mass of 24205 Dalton. Artemin is purified by proprietary chromatographic techniques.
Description : The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenrative disease. Artemin has been shown in culture to support the survival of a number of periferal neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Four alternatively spliced transcripts have been described, two of which encode the same protein.
Source : Escherichia Coli.
Amino acid sequence : The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Gly-Gly-Pro-Gly.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Purity : Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : Artemin was lyophilized after extensive dialysis against 10mM sodium citrate pH-4.5 and 150mM sodium chloride.
Solubility : It is recommended to reconstitute the lyophilized Artemin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Biological Activity : The Biological activity is calculated by it"s ability to promote survival and neurite outgrowth and dorsal root ganglion neurons.
Storage : Lyophilized Artemin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Artemin should be stored at 4°Cbetween 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : ARTN artemin [ Homo sapiens ]
Synonyms : ARTN; Artemin; EVN; NBN; ENOVIN; neurotrophic factor artemin; Neublastin; neurotrophic factor; artemin; neublastin; Enovin; OTTHUMP00000009173; OTTHUMP00000009174
Gene ID : 9048
mRNA Refseq : NM_001136215
Protein Refseq : NP_001129687
MIM : 603886
UniProt ID : Q5T4W7
Chromosome Location : 1p33-p32
Function : growth factor activity

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