Recombinant Human CDH13, GST-tagged

• Cat.No.: CDH13-11031H
• Product Overview: Recombinant Human CDH13 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: C-term-350a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CDH13 cadherin 13, H-cadherin (heart) [ Homo sapiens ]
• Official Symbol: CDH13
• Synonyms: CDH13; cadherin 13, H-cadherin (heart); cadherin-13; CDHH; T cadherin; T-cad; H-cadherin; T-cadherin; heart cadherin; P105
• Gene ID: 1012
• mRNA Refseq: NM_001220488
• Protein Refseq: NP_001207417
• MIM: 601364
• UniProt ID: P55290
• Chromosome Location: 16q23.3
• Pathway: Adherens junctions interactions, organism-specific biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem
• Function: adiponectin binding; cadherin binding; calcium ion binding; lipoprotein particle binding; low-density lipoprotein particle binding