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Recombinant Human DAD1, GST-tagged

Cat.No.: DAD1-11817H
Product Overview: Recombinant Human DAD1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes.
Source: E.coli
Species: Human
Tag: GST
Protein length: 1-113a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: DAD1 defender against cell death 1 [ Homo sapiens ]
Official Symbol: DAD1
Synonyms: DAD1; defender against cell death 1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; oligosaccharyltransferase 2 homolog (S. cerevisiae); OST2; DAD-1; oligosaccharyltransferase 2 homolog; oligosaccharyl transferase subunit DAD1;
Gene ID: 1603
mRNA Refseq: NM_001344
Protein Refseq: NP_001335
MIM: 600243
UniProt ID: P61803
Chromosome Location: 14q11.2
Pathway: Asparagine N-linked glycosylation, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; N-Glycan biosynthesis, organism-specific biosystem; N-Glycan biosynthesis, conserved biosystem; Oligosaccharyltransferase, organism-specific biosystem; Post-translational protein modification, organism-specific biosystem;
Function: contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity; contributes_to oligosaccharyl transferase activity; transferase activity;

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