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Recombinant Human NR0B1, His-tagged

Cat.No.: NR0B1-11833H
Product Overview: Recombinant Human NR0B1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description: This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
Source: E.coli
Species: Human
Tag: His
Protein length: 202-380a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name: NR0B1 nuclear receptor subfamily 0, group B, member 1 [ Homo sapiens ]
Official Symbol: NR0B1
Synonyms: NR0B1; nuclear receptor subfamily 0, group B, member 1; AHC, dosage sensitive sex reversal , DSS; nuclear receptor subfamily 0 group B member 1; AHCH; DAX1; nuclear receptor DAX1; nuclear receptor DAX-1; nuclear hormone receptor; DSS-AHC critical region on the X chromosome protein 1; AHC; AHX; DSS; GTD; HHG; DAX-1; NROB1; SRXY2;
Gene ID: 190
mRNA Refseq: NM_000475
Protein Refseq: NP_000466
MIM: 300473
UniProt ID: P51843
Chromosome Location: Xp21.3
Pathway: Androgen Receptor Signaling Pathway, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Nuclear Receptors, organism-specific biosystem; Regulation of Androgen receptor activity, organism-specific biosystem;
Function: AF-2 domain binding; DNA binding; DNA hairpin binding; RNA binding; double-stranded DNA binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; ligand-activated sequence-specific DNA binding RNA polymerase

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